Group Leader

profile_image
Dr. Asifa Akhtar
Senior Group Leader and Managing Director
Phone:+49 761 5108 565

Lab Asifa Akhtar

Assistant: Linda Schmidl phone: +49 761 5108 564 Email: schmidl@ie-freiburg.mpg.de

Laboratory Asifa Akhtar

The role of non-coding RNA in epigenetic regulation

<p>The protein MLE grabs the RNA strand like a monkey grabs a liana. One site serves as a simple anchor (feet), while the other is able to mould the strand. This consumes energy (banana). The moulded RNA allows other proteins to bind and thus to activate the X chromosome in male flies.</p> Zoom Image

The protein MLE grabs the RNA strand like a monkey grabs a liana. One site serves as a simple anchor (feet), while the other is able to mould the strand. This consumes energy (banana). The moulded RNA allows other proteins to bind and thus to activate the X chromosome in male flies.

[less]

Long non-coding RNAs (lncRNAs) are emerging as important regulators of chromatin state and transcription in eukaryotic cells. They can contribute to the regulation of single genes or whole chromosomes and can influence the 3-D structure of large genomic regions. Due to their length, which typically is in the range of kilobases, it has been difficult to understand their exact contributions to transcriptional regulation. Interestingly, the dosage compensation complex includes two long non-coding roX RNAs. However, the mechanism by which these RNAs function is poorly understood. Our recent work has shown that roX RNAs harbor several binding sites for MSL complex members thus providing a platform for complex assembly. One of our future aims will be to elucidate how RNA-protein interactions regulate transcriptional and post-transcriptional events and thereby influencing cellular homeostasis. 

 
loading content