The role of the NSL complex in gene regulation
Our earlier work identified that in addition to the MSL complex the MOF histone acetyltransferase is part of an evolutionary conserved Non-Specific Lethal (NSL) complex in Drosophila and mammals. Members of this complex are essential for male and female Drosophila.
We have subsequently shown that the NSL complex a chromatin bound complex that is enriched on promoters of target genes. Furthermore, it appears to be a major regulator of expression of housekeeping genes in Drosophila. We are currently exploring how this complex alone or in association with MOF regulates gene expression. We are also interested in studying how MOF activity is regulated in the NSL complex.