Group Leader

profile_image
Dr. Asifa Akhtar
Senior Group Leader and Managing Director
Phone:+49 761 5108 565

Lab Asifa Akhtar

Assistant: Linda Schmidl phone: +49 761 5108 564 Email: schmidl@ie-freiburg.mpg.de

Laboratory Asifa Akhtar

The role of the NSL complex in gene regulation

The Non-Specific-Lethal (NSL) Complex binds to all chromosomes. It is enriched on promoter regions and is involved in the regulation of many housekeeping genes in Drosophila. Zoom Image
The Non-Specific-Lethal (NSL) Complex binds to all chromosomes. It is enriched on promoter regions and is involved in the regulation of many housekeeping genes in Drosophila. [less]

Our earlier work identified that in addition to the MSL complex the MOF histone acetyltransferase is part of an evolutionary conserved Non-Specific Lethal (NSL) complex in Drosophila and mammals. Members of this complex are essential for male and female Drosophila.

We have subsequently shown that the NSL complex a chromatin bound complex that is enriched on promoters of target genes. Furthermore, it appears to be a major regulator of expression of housekeeping genes in Drosophila. We are currently exploring how this complex alone or in association with MOF regulates gene expression. We are also interested in studying how MOF activity is regulated in the NSL complex.

 
loading content