Max Planck Institute of Immunbiology and Epigenetics, Freiburg
Developmental and Evolutionary Biology & Genetics Immunobiology and Infection Biology & Medicine
Type of Job
Postdoc in Epigenetics of Neurodegeneration
Job offer from February 17, 2017
The Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany is offering a Postdoctoral Position in Epigenetics of neurogeneration in the independent laboratory of Dr. Ritwick Sawarkar. The position is available for a two-year appointment as soon as possible.
Our Institute investigates the molecular basis of the immune response and other topics of the developmental biology, such as the origin and differentiation of the immune cells as well as the development of vertebrate embryo. Another main focus of the Institute is Epigenetics. This area deals with inheritable traits, which are not caused by changes in the DNA sequence.
The host lab of Dr. Ritwick Sawarkar studies how epigenetic regulation controls protein-folding capacity of a cell. Chromatin modifications at genes encoding chaperones are cell-type-specific; consequently certain cell-types such as neurons have an altered chaperone profile. Could this be one of the reasons for sensitivity of neurons to protein misfolding diseases? If so, could we use epigenetic therapy for neurodegeneration? Join our international team in Freiburg to explore these exciting questions! The working language is English.
For further scientific details, please see the following papers:
- Hummel B, Hansen E, Yoveva A, Aprile-Garcia F, Hussong R and Sawarkar R (2017) The evolutionary capacitor HSP90 buffers the regulatory effects of endogenous retroviruses. Nature Structural and Molecular Biology. doi: 10.1038/nsmb.3368
- Sawarkar R., Sievers C. and Paro R. (2012) Hsp90 globally targets paused RNA polymerase to regulate gene expression in response to environmental stimuli. Cell 149, 807-818.
- Sawarkar R. and Paro R. (2010) Interpretation of developmental signaling at chromatin: the Polycomb perspective. Dev Cell 19, 651-661.
Applicants should have a Ph.D or equivalent doctoral degree in any area of Biology, with a good publication record. Experience with molecular biology techniques is required and some knowledge of genomics, proteomics is desired. Ability to work in a team, communication skills and experience in the supervision of graduate students are an asset.
If you want to be at the cutting edge of interdisciplinary research and make fundamental discoveries impacting biomedicine, then we are looking for you!
Salary will be based on previous experience according to TVöD guidelines.
Handicapped applicants with equal qualifications will be given preferential treatment. The Max Planck Society seeks to increase the number of women in areas, where they are underrepresented, and therefore explicitly encourages women to apply. A childcare facility is directly attached to the Institute.
Have we sparked your interest? Please submit your complete application including a statement of research interests and a CV directly via our online application portal until March 31st 2017.
Max Planck Institute of Immunobiology and Epigenetics