Group Leader

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Dr. Eirini Trompouki
Group Leader
Phone:+49 761 5108 550

Lab Eirini Trompouki

Selected Publications

1.
Trompouki E (2015)
Fish provide ID(H)eas on targeting leukemia
2.
Lin MI, Price EN, Boatman S, Hagedorn EJ, Trompouki E, Satishchandran S, Carspecken CW, Uong A, DiBiase A, Yang S, Canver MC, Dahlberg A, Lu Z, Zhang CC, Orkin SH, Bernstein ID, Aster JC, White RM and Zon LI (2015)
Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling
3.
Xu C, Fan ZP, Müller P, Fogley R, DiBiase A, Trompouki E, Unternaehrer J, Xiong F, Torregroza I, Evans T, Megason SG, Daley GQ, Schier AF, Young RA, Zon LI. (2012)
Nanog-like regulates endoderm formation through the Mxtx2-Nodal pathway
4.
Trompouki E, Bowman TV, Lawton LN, Fan ZP, Wu DC, DiBiase A, Martin CS, Cech JN, Sessa AK, Leblanc JL, Li P, Durand EM, Mosimann C, Heffner GC, Daley GQ, Paulson RF, Young RA, Zon LI (2011)
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration
5.
Trompouki E, Bowman TV, Dibiase A, Zhou Y, Zon LI (2011)
Chromatin immunoprecipitation in adult zebrafish red cells

Laboratory Eirini Trompouki

Laboratory Eirni Trompouki

Hematopoiesis is the process of generating new cells of all the blood lineages. Exceedingly rare hematopoietic stem cells (HSCs) are responsible for maintaining the balance between different blood lineages and replenishing the system in case of stress such as infection, trauma or irradiation. Signal transduction pathways continuously deliver information to the cells by mediating the actions of signaling transcription factors.

We are particularly interested in inflammatory pathways that have been recently implicated in HSC quiescence and regeneration. HSCs were thought to respond to inflammatory signals indirectly, just to replenish immune hematopoietic cells. Only lately, it has been proven that HSCs can directly sense and respond to inflammatory signals, not only in cases of infection but also under steady state conditions. Acute inflammatory signaling affects HSC quiescence and chronic exposure can lead to HSC exhaustion and may cause hematopoietic malignancies.

Using zebrafish and mice as model organisms we want to understand how these pathways control HSC quiescence, and affect hematopoietic differentiation and regeneration. We are mainly interested in studying how inflammatory signals formulate the transcriptional landscape of HSCs. The ultimate goal is to understand how we can manipulate hematopoietic stem cells and improve hematopoietic outcomes during stress and disease.

 
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