Recent publications by IMPRS PhD fellows

1.
Chlamydas S*, Holz H*, Samata M*, Chelmicki T, Georgiev P, Pelechano V, Dündar F, Dasmeh P, Mittler G, Cadete FT, Ramírez F, Conrad T, Wei W, Raja S, Manke T, Luscombe NM, Steinmetz LM, Akhtar A. (2016).

 Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation.

2.
Levit-Zerdoun E, Becker M, Pohlmeyer R, Wilhelm I, Maity PC, Rajewsky K, Reth M, Hobeika E. (2016)
Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function.
3.
Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity.
Dalgaard K, Landgraf K, Heyne S, Lempradl A, Longinotto J, Gossens K, Ruf M, Orthofer M, Strogantsev R, Selvaraj M, Lu TT, Casas E, Teperino R, Surani MA, Zvetkova I, Rimmington D, Tung YC, Lam B, Larder R, Yeo GS, O'Rahilly S, Vavouri T, Whitelaw E, Penninger JM, Jenuwein T, Cheung CL, Ferguson-Smith AC, Coll AP, Körner A, Pospisilik JA.
4.
Pfefferkorn C, Kallfass C, Lienenklaus S, Spanier J, Kalinke U, Rieder M, Conzelmann KK, Michiels T, Staeheli P (2015).
Abortively Infected Astrocytes Appear To Represent the Main Source of Interferon Beta in the Virus-Infected Brain.
5.
Gronke K, Diefenbach A.
Regenerative biology: Innate immunity repairs gut lining.Regenerative biology: Innate immunity repairs gut lining.
6.
Lupar E, Brack M, Garnier L, Laffont S, Rauch KS, Schachtrup K, Arnold SJ, Guéry JC, Izcue A.

Eomesodermin Expression in CD4+ T Cells Restricts Peripheral Foxp3 Induction.

7.
Ramirez F*, Lingg T*, Toscano S*, Lam KC*, Georgiev P, Chung H, Lajoie BR, de Wit E, Zhan Y, de Laat W, Dekker J, Manke T, Akhtar A

High-Affinity Sites form an interaction network to facilitate spreading of the MSL complex across the X chromosome in Drosophila.

8.
Bremser A, Brack M, Izcue A.
Higher Sensitivity of Foxp3+ Treg Compared to Foxp3- Conventional T Cells to TCR-Independent Signals for CD69 Induction.
9.
Meunier S *, Shvedunova M *, Van Nguyen N, Avila L, Vernos I and Akhtar A. (2015)
An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
10.
Hernández PP*, Mahlakõiv T*, Yang I, Schwierzeck V, Nguyen N, Guendel F, Gronke K, Ryffel B, Hölscher C, Dumoutier L, Renauld JC, Suerbaum S, Staeheli P, Diefenbach A
Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection.

Our Faculty

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Our Faculty

Currently, 33 group leaders are members of the IMPRS program and are affiliated either to the Max Planck Institute of Immunobiology and Epigenetics, the University of Freiburg or the Max Planck Research Department of Systems Immunology in Würzburg. Their research focuses on epigenetics, immunobiology, metabolism, functional genomics, biochemistry, non-coding RNAs, and cell biology.
Project areas: Non-coding RNA in dosage-compensation Chromosome dynamics and gene expression The role of the NSL complex in gene regulation Function of the mammalian MSL and NSL complexes

Dr Asifa Akhtar

Project areas:
Non-coding RNA in dosage-compensation
Chromosome dynamics and gene expression
The role of the NSL complex in gene regulation
Function of the mammalian MSL and NSL complexes [more]
Project areas:Thymus development and functionGenetics of thymopoiesis and T cell development in vertebrates Evolution of adaptive immune systems

Dr Thomas Boehm

Project areas:
Thymus development and function
Genetics of thymopoiesis and T cell development in vertebrates
Evolution of adaptive immune systems [more]
Project areas:Take snapshots of a metabolic state by metabolite quantificationStudy metabolic pathway usage by 13C label tracing

Dr Jörg Büscher

Project areas:
Take snapshots of a metabolic state by metabolite quantification
Study metabolic pathway usage by 13C label tracing [more]
Project areas:Regulation of hematopoietic and leukemic stem cell quiescenceRegulation of the hematopoietic stem cell niche

Dr Nina Cabezas-Wallscheid

Project areas:
Regulation of hematopoietic and leukemic stem cell quiescence
Regulation of the hematopoietic stem cell niche [more]
Project areas:Signaling in tissue stress responsesCell proliferation during regeneration and cancerEpigenetic and chromatin plasticityActomyosin contractility and cell-cell adhesion in epithelial tissues

Dr Anne Classen

Project areas:
Signaling in tissue stress responses
Cell proliferation during regeneration and cancer
Epigenetic and chromatin plasticity
Actomyosin contractility and cell-cell adhesion in epithelial tissues [more]
Project areas:Our current major research focus is on clear cell renal cell carcinoma, the most frequent form of kidney cancer. We ask how different combinations of genetic mutations in tumour suppressor and oncogenic signalling pathways affect the behaviours of tumours and their responses to therapies. We use mouse genetics, cell culture and analyses of human tumour tissues to understand the tumour immune microenvironment and to develop ways to manipulate this therapeutically.

Prof. Dr. Ian Frew

Project areas:
Our current major research focus is on clear cell renal cell carcinoma, the most frequent form of kidney cancer. We ask how different combinations of genetic mutations in tumour suppressor and oncogenic signalling pathways affect the behaviours of tumours and their responses to therapies. We use mouse genetics, cell culture and analyses of human tumour tissues to understand the tumour immune microenvironment and to develop ways to manipulate this therapeutically. [more]
Project areas:Local players in immunity: development, functions and tissue-niches of resident innate lymphoid and memory cellsA systems immunology view of multicellular immune responses

Prof Dr Georg Gasteiger

Project areas:
Local players in immunity: development, functions and tissue-niches of resident innate lymphoid and memory cells
A systems immunology view of multicellular immune responses [more]
Project areas:Mechanisms of Inflammatory Processes mediated by the innate immune systemInflamasome biology in auto-inflammatory diseasesCellular metabolism and the immune system

Prof. Dr. Olaf Groß

Project areas:
Mechanisms of Inflammatory Processes mediated by the innate immune system

Inflamasome biology in auto-inflammatory diseases
Cellular metabolism and the immune system [more]
Project areas: Regulatory Circuitries of B Lymphopoiesis Stem cell pluripotency and higher-order chromatin structure Role of Mzb1 in peripheral B cell subsets

Prof Dr Rudolf Grosschedl

Project areas:
Regulatory Circuitries of B Lymphopoiesis
Stem cell pluripotency and higher-order chromatin structure
Role of Mzb1 in peripheral B cell subsets [more]
Project areas:
Studying  cellular differentiation and plasticity with quantitative single-cell methods (single-cell RNA-seq, imaging) in the immune system or the liverInvestigating the role and regulation of gene expression variability during cell fate decisionDeveloping experimental or computational methods for quantitative single-cell analysis
 

Dr Dominic Grün

Project areas:
Studying  cellular differentiation and plasticity with quantitative single-cell methods (single-cell RNA-seq, imaging) in the immune system or the liver
Investigating the role and regulation of gene expression variability during cell fate decision
Developing experimental or computational methods for quantitative single-cell analysis
 
[more]
Project areas:Invasion and metastasis of colorectal cancer cellsRegulatory networks initiating and executing epithelial-mesenchymal transitionsFunctional interplay of transcription factors and chromatin structure at cis-regulatory DNA elements

Prof Dr Andreas Hecht

Project areas:
Invasion and metastasis of colorectal cancer cells
Regulatory networks initiating and executing epithelial-mesenchymal transitions
Functional interplay of transcription factors and chromatin structure at cis-regulatory DNA elements
Project areas:Function of alternative 3' UTRs in neuronal processesMechanism of RNA processing in neurons

Dr Valérie Hilgers

Project areas:
Function of alternative 3' UTRs in neuronal processes
Mechanism of RNA processing in neurons [more]
Project areas: Epigenetic regulation of gametogenesis Establishment of totipotency and epigenetic reprogramming Transgenerational epigenetic inheritance

Dr Nicola Iovino

Project areas:
Epigenetic regulation of gametogenesis
Establishment of totipotency and epigenetic reprogramming
Transgenerational epigenetic inheritance [more]
Project areas:
B cell activation and differentiationIntegration of cell signaling and metabolism in B cellsRegulation of the germinal center response

Dr Julia Jellusova

Project areas:

B cell activation and differentiation
Integration of cell signaling and metabolism in B cells
Regulation of the germinal center response

[more]
Project areas: How to make heterochromatin How to break heterochromatin Genome-wide signatures for heterochromatin

Dr Thomas Jenuwein

Project areas:
How to make heterochromatin
How to break heterochromatin
Genome-wide signatures for heterochromatin [more]
Dynamics of memory CD8+ T cells function and developmentPathogen defense in secondary lymphoid organsMigration and dynamics of Dendritic Cells within tissues

Prof. Dr. Wolfgang Kastenmüller

Dynamics of memory CD8+ T cells function and development
Pathogen defense in secondary lymphoid organs
Migration and dynamics of Dendritic Cells within tissues [more]
Project areas:How cells move, communicate and coordinate their dynamic behavior during an innate immune response

Dr Tim Lämmermann

Project areas:
How cells move, communicate and coordinate their dynamic behavior during an innate immune response [more]
Project areas:Deep sequencing data analysisEpigenomics and chromatin structureRegulation of gene expression and transcription factor binding

Dr Thomas Manke

Project areas:
Deep sequencing data analysis
Epigenomics and chromatin structure
Regulation of gene expression and transcription factor binding [more]
Project areas:Our lab aims to uncover signalling mechanisms that control reprogramming of mitochondrial functions upon metabolic switches, changing cell cycle phases and ongogenesis.

Prof Dr Chris Meisinger

Project areas:
Our lab aims to uncover signalling mechanisms that control reprogramming of mitochondrial functions upon metabolic switches, changing cell cycle phases and ongogenesis. [more]
Project areas:Developing custom-tailored protein (-complex) purification and MS analysis strategies for defined biological questionsState-of-the-art Mass Spectrometry (MS) analysis service

Dr Gerhard Mittler

Project areas:
Developing custom-tailored protein (-complex) purification and MS analysis strategies for defined biological questions
State-of-the-art Mass Spectrometry (MS) analysis service [more]
Project areas:Metabolic reprogramming in memory T cellsPost-transcriptional regulation of T cell function by metabolic enzymesImmune cell metabolism in the tumor microenvironment

Dr Erika Pearce

Project areas:
Metabolic reprogramming in memory T cells
Post-transcriptional regulation of T cell function by metabolic enzymes
Immune cell metabolism in the tumor microenvironment

[more]
Project areas:Intracellular transport of proteinsBiogenesis and architecture of mitochondriaAssembly of mitochondrial protein complexes

Prof Dr Nikolaus Pfanner

Project areas:
Intracellular transport of proteins
Biogenesis and architecture of mitochondria
Assembly of mitochondrial protein complexes [more]
Project areas: Regulation of ubiquitination by the E2-enzyme E2-25K Regulation of sumoylation by its sole E2 enzyme Ubc9

Dr Andrea Pichler

Project areas:
Regulation of ubiquitination by the E2-enzyme E2-25K
Regulation of sumoylation by its sole E2 enzyme Ubc9 [more]
Project areas: Epigenetic mapping of mammalian disease  Functional translation of epigenetic cues

Dr Andrew Pospisilik

Project areas:
Epigenetic mapping of mammalian disease
Functional translation of epigenetic cues [more]
Project areas:Origin, fate and function of tissue macrophages in the CNSNeuroimmunologyNeudegeneration

Prof Dr Marco Prinz

Project areas:
Origin, fate and function of tissue macrophages in the CNS
Neuroimmunology
Neudegeneration [more]
Project areas:Dynamics of morphogen signaling Cell and developmental biology of BMP signaling Cis-regulatory principles in developmental signaling and patterning

Dr Giorgos Pyrowolakis

Project areas:
Dynamics of morphogen signaling
Cell and developmental biology of BMP signaling
Cis-regulatory principles in developmental signaling and patterning [more]
Project areas:How cells use their organellar infrastructure to mount a protective immune response. Defining different mechanisms of interorganellar communication.

Dr Angelika Rambold

Project areas:
How cells use their organellar infrastructure to mount a protective immune response.
Defining different mechanisms of interorganellar communication.

[more]
Project areas: Epigenetics of bacterial infectionHost-pathogen interactions in super-resolution Physiological role of bacterial lectins on immune cells Reconstitution of cellular processes on synthetic membrane systems

Jun-Prof Dr Winfried Römer

Project areas:
Epigenetics of bacterial infection
Host-pathogen interactions in super-resolution
Physiological role of bacterial lectins on immune cells
Reconstitution of cellular processes on synthetic membrane systems

[more]
Project areas:Crosstalk between chromatin factors and RNA pol II pausing Nuclear proteostasis in transcriptional dynamics

Dr Ritwick Sawarkar

Project areas:
Crosstalk between chromatin factors and RNA pol II pausing
Nuclear proteostasis in transcriptional dynamics [more]
Project areas:Histone methylation in cancerEpigenetic control of gene transcriptionProteomic analyses of transcription and chromatin complexesOur lab in Freiburg started in July 2017 and we are actively recruiting.

Prof Dr Marc Timmers

Project areas:
Histone methylation in cancer
Epigenetic control of gene transcription
Proteomic analyses of transcription and chromatin complexes

Our lab in Freiburg started in July 2017 and we are actively recruiting. [more]
Project areas:How signalling pathways and especially inflammatory pathways influence hematopoietic stem cells decisions.

Dr Eirini Trompouki

Project areas:
How signalling pathways and especially inflammatory pathways influence hematopoietic stem cells decisions. [more]
My research group has its focus on tumor immunology and immune regulation after allogeneic hematopoietic stem cell transplantation. In this context we study different types of innate immune cells in organs affected by graft-versus-host diesease. We track these cells by in vivo imaging methods and light sheet microscopy.

Prof Dr Robert Zeiser

My research group has its focus on tumor immunology and immune regulation after allogeneic hematopoietic stem cell transplantation. In this context we study different types of innate immune cells in organs affected by graft-versus-host diesease. We track these cells by in vivo imaging methods and light sheet microscopy. [more]

 
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