from Cuernavaca, Mexico IMPRS fellow since October 2014 in Iovino lab
In mammals and many other sexually reproducing organisms one of the major events of reprogramming occurs after fertilization, when gametes give rise to a totipotent zygote. This process is particularly relevant for the paternal gamete that has to switch from mainly protamine-based to a nucleosome chromatin structure to allow pronuclei fusion. Although this series of events has been well characterised by light and fluorescence microscopy, very little is known at the mechanistic level about the early events that contribute to the unpacking of the chromatin of the sperm. During my PhD, I aim to unravel the molecular mechanisms that lead to de novo chromatin assembly using sperm chromatin remodeling as a model system.