Mast cells are tissue-resident cells that are found in most tissues of the body, especially in locations in close contact with the external environment. In peripheral tissues, subsets of mast cells align closely to anatomical structures (e.g. blood vessels). How such site-specific tissue localization is molecularly controlled has not been investigated yet. The aim of my Ph.D. thesis is to investigate how MCs distribute in interstitial tissues and if their site-specific localization plays an important role during inflammatory reactions.
Sarah K. Bambach, Tim Lämmermann (2017). Platelets, On Your Marks, Get Set, Migrate! Cell 2017 Nov 30;171(6):1256-1258.