from Munich, Germany IMPRS fellow since January 2015 in Lämmermann lab
Research interests Neutrophils are essential cells of the innate immune system for clearing infections or damaged tissue. Upon tissue injury, individual neutrophils communicate with each other and swarm towards local sites of cell death in inflamed tissues by a multistep process until resolution of the tissue damage. While key regulatory molecules for the initial phases of neutrophil swarming have been identified, it is completely unknown how neutrophil swarming in vivo is stopped and how inflammatory cell aggregates are resolved during the late phases of inflammation. The aim of my Ph.D. thesis in the lab of Dr. Tim Lämmermann is to investigate control mechanisms that regulate the elimination of inflammatory cell clusters. Hopefully, new molecular insights may prove useful for innovative therapeutic strategies to modulate tissue regeneration after inflammation and infection.
Publications Kienle K and Lämmermann T. (2016). Neutrophil swarming: an essential process of the neutrophil tissue response. Immunol Rev. 2016 Sep;273(1):76-93.