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Dr. Erika  Pearce
Dr. Erika Pearce
Senior-Gruppenleiterin und Direktorin
E-Mail:pearce@...

Labor Erika Pearce

Assistenz: Kimberly Mueller Tel: +49 761 5108 450 E-Mail: mueller@ie-freiburg.mpg.de

Labor Erika Pearce

Publikationen

  1. 2021
    Stanczak, M. A.; Sanin, P. D. E.; Apostolova, P.; Nerz, G.; Lampaki, D.; Hofmann, M.; Steinmann, D.; Krohn-Grimberghe, M.; Thimme, R.; Mittler, G. et al.; Waller, C. F.; Pearce, E. J.; Pearce, E. L.: IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals. Nature Communications 12, S. 2133 (2021)
  2. Villa, M.; Stanczak, M. A.; Pearce, E. L.: How to make a better T cell: in vivo CRISPR screens have some answers. Cell 184, S. 1135 - 1136 (2021)
  3. Corrado, M.; Samardžić, D.; Giacomello, M.; Rana, N.; Pearce, E. L.; Scorrano, L.: Deletion of the mitochondria-shaping protein Opa1 during early thymocyte maturation impacts mature memory T cell metabolism. Cell Death and Differentiation (2021)
  4. Kelly, B.; Carrizo, G. E.; Edwards-Hicks, J.; Sanin, P. D. E.; Stanczak, M. A.; Priesnitz, C.; Flachsmann, L. J.; Jonathan, D. C.; Mittler, G.; Musa, Y. et al.; Becker, T.; Büscher, J. M.; Pearce, E. L.: Sulfur sequestration promotes multicellularity during nutrient limitation. Nature, S. 1 - 6 (2021)
  5. 2020
    Edwards-Hicks, J.; Mitterer, M.; Pearce, E. L.; Buescher, J. M.: Metabolic Dynamics of In Vitro CD8+ T Cell Activation. Metabolites 11, S. 12 (2020)
  6. Corrado, M.; Edwards-Hicks, J.; Villa, M.; Flachsmann, L. J.; Sanin, P. D. E.; Jacobs, M.; Baixauli Celda, F.; Stanczak, M.; Anderson, E.; Azuma, M. et al.; Quintana, A.; Jonathan, C.; Clapes, T.; Grzes, K.; Kabat, A.; Ryan, K.; Annette, E. P.; Klein-Geltink, R.; Amulic, B.; Steward, C. G.; Strathdee, D.; Trompouki, E.; O'Sullivan, D.; Pearce, E. J.; Pearce, E. L.: Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity. Cell Metabolism 32, S. 981 - 995 (2020)
  7. Uhl, F. M.; Chen, S.; O'Sullivan, D.; Edwards-Hicks, J.; Richter, G.; Haring, E.; Andrieux, G.; Halbach, S.; Apostalova, P.; Büscher, J. M. et al.; Duquesne, S.; Melchinger, W.; Sauer, B.; Shoumariyeh, K.; Schmitt-Graeff, A.; Kreutz, M.; Lübbert, M.; Duyster, J.; Brummer, T.; Boerries, M.; Madl, T.; Blazar, B. R.; Groß, O.; Pearce, E. L.; Zeiser, R.: Metabolic reprogramming of donor T cells enhances graf-versus-leukemia effects in mice and humans. Science Translational Medicine 12, S. eabb8969 (2020)
  8. Kelly, B.; Pearce, E. L.: Amino Assets: How Amino Acids Support Immunity. Cell Metabolism 32, S. 154 - 175 (2020)
  9. Klein-Geltink, R.; Edwards-Hicks, J.; Apostolova, P.; O'Sullivan, D.; Sanin, P. D. E.; Annette, E. P.; Puleston, D.; Ligthart, N. A. M.; Büscher, J. M.; Grzes, K. et al.; Kabat, A.; Stanczak, M.; Curtis, J.; Hässler, F.; Uhl, F. M.; Fabri, M.; Zeiser, R.; Pearce, E. J.; Pearce, E. L.: Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy. Nature Metabolism 2, S. 703 - 716 (2020)
  10. Haring, E.; Uhl, F. M.; Andrieux, G.; Proietti, M.; Bulashevska, A.; Sauer, B.; Braun, L. M.; de Gomez, E. V.; Esser, P. R.; Martin, S. F. et al.; Pfeifer, D.; Follo, M.; Schmitt-Graeff, A.; Büscher, J. M.; Duyster, J.; Grimbacher, B.; Boerries, M.; Pearce, E. L.; Zeiser, R.; Apostolova, P.: Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect. Haematologica (2020)
  11. Milam, A. A. V.; Bartleson, J. M.; Buck, M. D.; Chang, C.-H.; Sergushichev, A.; Donermeyer, D. L.; Lam, W. Y.; Pearce, E. L.; Artyomov, M. N.; Allen, P. M.: Tonic TCR Signaling Inversely Regulates the Basal Metabolism of CD4+ T Cells. ImmunoHorizons 4, S. 485 - 497 (2020)
  12. Almeida, R. R.; de Vieira, R. S.; Castoldi, A.; Terra, F. F.; Melo, A. C. L.; Canesso, M. C. C.; Lemos, L.; Cipelli, M.; Rana, N.; Hiyane, M. I. et al.; Pearce, E. L.; Martins, F. d. S.; de Câmara, A. M. C. F. &. N. O. S.: Host dysbiosis negatively impacts IL-9-producing T-cell differentiation and antitumour immunity. British Journal of Cancer 123, S. 534 - 541 (2020)
  13. Puleston, D.; Pearce, E. L.: Appetite for Arginine: Metabolic Control of Macrophage Hunger. Cell Metabolism 31, S. 441 - 442 (2020)
  14. Angiari, S.; Runtsch, M. C.; Sutton, C. E.; Palsson-McDermott, E. M.; Kelly, B.; Rana, N.; Kane, H.; Papadopoulou, G.; Pearce, E. L.; Mills, K. H.G. et al.; O'Neill, L. A.J.: Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+-T Cell Pathogenicity and Suppresses Autoimmunity. Cell Metabolism 31, S. 391 - 405 (2020)
  15. Field, C.; Baixauli Celda, F.; Puleston, D.; Kyle, R.; Alana, C.; Sanin, P. D. E.; Hippen, K. L.; Loschi, M.; Thangavelu, G.; Corrado, M. et al.; Edwards-Hicks, J.; Grzes, K.; Pearce, E. J.; Blazar, B. R.; Pearce, E. L.: Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function. Cell Metabolism 31, S. 422 - 437 (2020)
  16. Castoldi, A.; Monteiro, L. B.; van Bakker, N. T.; Sanin, D. E.; Rana, N.; Corrado, M.; Cameron, A. M.; Hässler, F.; Matsushita, M.; Caputa, G. et al.; Geltink, R. I. K.; Büscher, J.; Edwards-Hicks, J.; Pearce, E. L.; Pearce, E. J.: Triacylglycerol synthesis enhances macrophage inflammatory function. Nature Communications 11, S. 1 - 11 (2020)
  17. Kapoor, T.; Corrado, M.; Pearce, E. L.; Pearce, E. J.; Grosschedl, R.: MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells. Scientific Reports 10 (2020)
  18. Ramamoorthy, S.; Kometani, K.; Herman, J. S.; Bayer, M.; Boller, S.; Edwards-Hicks, J.; Ramachandran, H.; Li, R.; Klein-Geltink, R.; Pearce, E. L. et al.; Grün, D.; Grosschedl, R.: EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism. Genes and Development 34, S. 1503 - 1519 (2020)
  19. 2019
    O'Sullivan, D.; Sanin, P. D. E.; Pearce, E. J.; Pearce, E. L.: Metabolic interventions in the immune response to cancer. Nature Reviews Immunology 19, S. 324 - 334 (2019)
  20. Cameron, A. M.; Castoldi, A.; Sanin, D. E.; Flachsmann, L. J.; Field, C. S.; Puleston, D. J.; Kyle, R. L.; Patterson, A.; Hassler, F.; Buescher, J. M. et al.; Kelly, B.; Pearce, E. L.; Pearce, E. J.: Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species-mediated DNA damage. Nature Immunology 20, S. 420 - 432 (2019)
  21. Mateo, V.; Baixauli Celda, F.; Pearce, E. L.: Potassium shapes antitumor immunity. Science 363, S. 1395 - 1396 (2019)
  22. Puleston, D. J.; Buck, M. D.; Geltink, R. I. K.; Kyle, R. L.; Caputa, G.; O’Sullivan, D.; Cameron, A. M.; Castoldi, A.; Musa, Y.; Kabat, A. M. et al.; Zhang, Y.; Flachsmann, L. J.; Field, C. S.; Patterson, A. E.; Scherer, S.; Alfei, F.; Baixauli, F.; Austin, S. K.; Kelly, B.; Matsushita, M.; Curtis, J. D.; Grzes, K. M.; Villa, M.; Corrado, M.; Sanin, D. E.; Qiu, J.; Pällman, N.; Paz, K.; Maccari, M. E.; Blazar, B. R.; Mittler, G.; Büscher, J.; Zehn, D.; Rospert, S.; Pearce, E. J.; Balabanov, S.; Pearce, E. L.: Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. Cell Metabolism 30, S. 1 - 12 (2019)
  23. Qui, J.; Mateo, V.; Sanin, D. E.; Buck, M. D.; O'Sullivan, D.; Ching, R.; Matsushita, M.; Grzes, K.; Winkler, F.; Chang, C.-H. et al.; Curtis, J.; Kyle, R.; Van Teijlingen, N.; Corrado, M.; Haessler, F.; Alfei, F.; Edwards-Hicks, J.; Maggi Jr., L. B.; Zehn, D.; Egawa, T.; Bengsch, B.; Klein-Geltink, R.; Jenuwein, T.; Pearce, E. J.; Pearce, E. L.: Acetate Promotes T Cell Effector Function during Glucose Restriction. Cell Reports 27, S. 2063 - 2074 (2019)
  24. 2018
    Sanin, D. E.; Matsushita, M.; Klein-Geltink, R.; Grzes, K.; van Bakker, N. T.; Corrado, M.; Kabat, A.; Buck, M. D.; Qiu, J.; Lawless, S. J. et al.; Cameron, A.; Villa, M.; Baixauli Celda, F.; Patterson, A. E.; Hässler, F.; Curtis, J. D.; O’Neill, C. M.; O'Sullivan, D.; Wu, D.; Mittler, G.; Huang, S. C.-C.; Pearce, E. L.; Pearce, E. J.: Mitochondrial Membrane Potential Regulates Nuclear Gene Expression Macrophages Exposed to Prostaglandin. Immunity 49, S. 1021 - 1033 (2018)
  25. Mathew, N. R.; Baumgartner, F.; Braun, L.; O'Sullivan, D.; Thomas, S.; Waterhouse, M.; Müller, T. A.; Hanke, K.; Taromi, S.; Apostolova, P. et al.; Illert, A. L.; Melchinger, W.; Duquesne, S.; Schmitt-Graeff, A.; Osswald, L.; Yan, K.-L.; Weber, A.; Tugues, S.; Spath, S.; Pfeifer, D.; Follo, M.; Claus, R.; Lübbert, M.; Rummelt, C.; Bertz, H.; Wäsch, R.; Haag, J.; Schmidts, A.; Schultheiss, M.; Bettinger, D.; Thimme, R.; Ullrich, E.; Tanriver, Y.; Vuong, G. L.; Arnold, R.; Hemmati, P.; Wolf, D.; Ditschkowski, M.; Jilg, C.; Wilhelm, K.; Leiber, C.; Gerull, S.; Halter, J.; Lengerke, C.; Pabst, T.; Schroeder, T.; Kobbe, G.; Rösler, W.; Doostkam, S.; Meckel, S.; Stabla, K.; Metzelder, S. K.; Halbach, S.; Brummer–, T.; Hu, Z.; Dengjel, J.; Hackanson, B.; Schmid, C.; Holtick, U.; Scheid, C.; Spyridonidis, A.; Stölzel, F.; Ordemann, R.; Müller, L. P.; Sicre-de-Fontbrune, F.; Ihorst, G.; Kuball, J.; Ehlert, J. E.; Feger, D.; Wagner, E.-M.; Cahn, J.-Y.; Schnell, J.; Kuchenbauer, F.; Bunjes, D.; Chakraverty, R.; Richardson, S.; Gill, S.; Kröger, N.; Ayuk, F.; Vago–, L.; Ciceri–, F.; Müller, A. M.; Kondo, T.; Teshima, T.; Klaeger, S.; Kuster, B.; Kim, D.; Weisdorf, D.; van der Velden, W.; Dörfel, D.; Bethge, W.; Hilgendorf, I.; Hochhaus, A.; Andrieux, G.; Börries, M.; Busch, H.; Magenau, J.; Reddy, P.; Labopin, M.; Antin, J. H.; Henden, A. S.; Hill–, G. R.; Kennedy, G. A.; Bar, M.; Sarma, A.; McLornan, D.; Mufti, G.; Oran, B.; Rezvani, K.; Shah, O.; Negrin, R. S.; Nagler, A.; Prinz, M.; Burchert, A.; Neubauer, A.; Beelen, D.; Mackensen, A.; von Bubnoff, N.; Herr, W.; Becher, B.; Socié, G.; Caligiuri, M. A.; Ruggiero–, E.; Bonini–, C.; Häcker, G.; Duyster, J.; Finke, J.; Pearce, E. L.; Blazar, B. R.; Zeiser, R.: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT-3-ITD-mutant leukemia cells. Nature Medicine 24, S. 282 - 291 (2018)
  26. Prestipino, A.; Emhardt, A. J.; Aumann, K.; O'Sullivan, D.; Gorantla, S. P.; Duquesne, S.; Melchinger, W.; Braun, L.; Vuckovic, S.; Boerries, M. et al.; Busch, H.; Halbach, S.; Pennisi, S.; Poggio, T.; Apostolova, P.; Veratti, P.; Hettich, M.; Niedermann, G.; Bartholomä, M.; Shoumariyeh, K.; Jutzi, J. S.; Wehrle, J.; Dierks, C.; Becker, H.; Schmitt-Graeff, A.; Follo, M.; Pfeifer, D.; Rohr, J.; Fuchs, S.; Ehl, S.; Hartl, F. A.; Minguet, S.; Miething, C.; Heidel, F. H.; Kröger, N.; Triviai, I.; Brummer, T.; Finke, J.; Illert, A. L.; Ruggiero, E.; Bonini, C.; Duyster, J.; Pahl, H. L.; Lane, S. W.; Hill, G. R.; Blazar, B. R.; von Bubnoff, N.; Pearce, E. L.; Zeiser, R.: Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms. Science Translational Medicine 10 (2018)
  27. Klein-Geltink, R.; Kyle, R. L.; Pearce, E. L.: Unraveling the Complex Interplay Between T Cell Metabolism and Function. Annual Reviews of Immunology 36, S. 461 - 488 (2018)
  28. Pearce, E. J.; Pearce, E. L.: Immunometabolism in 2017: Driving immunity: all roads lead to metabolism. Nature Reviews Immunology 18, S. 81 - 82 (2018)
  29. Piragyte, I.; Clapes, T.; Polyzou, A.; Geltink, R. I. K.; Lefkopoulos, S.; Yin, N.; Cauchy, P.; Curtis, J. D.; Klaeylé, L.; Langa, X. et al.; Beckmann, C. C. A.; Wlodarski, M. W.; Müller, P.; Essen, D. V.; Rambold, A.; Kapp, F. G.; Mione, M.; Buescher, J. M.; Pearce, E. L.; Polyzos, A.; Trompouki, E.: A metabolic interplay coordinatd by HLX regulates myeloid differentiation and AML through partly overlapping pathways. Nature Communications 9, S. 3090 (2018)
  30. Rambold, A.; Pearce, E. L.: Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function. Trends in Immunology 39, S. 6 - 18 (2018)
  31. Villa, M.; Jing, Q.; Pearce, E. L.: A Sweet Deal for Diabetes. Trends in Endocrinology and Metabolism 29, S. 1 - 2 (2018)
  32. 2017
    Gubin, M. M.; Zhang, X.; Schuster, H.; Caron, E.; Ward, J. P.; Noguchi, T.; Ivanova, Y.; Hundal, J.; Arthur, C. D.; Krebber, W.-J. et al.; Mulder, G. E.; Toebes, M.; Vesely, M. D.; Lam, S. S. K.; Korman, A. J.; Allison, J. P.; Freeman, G. J.; Sharpe, A. H.; Pearce, E. L.; Schumacher, T. N.; Aebersold, R.; Rammensee, H.-G.; Melief, C. J. M.; Mardis, E. R.; Gillanders, W. E.; Artyomov, M. N.; Schreiber, R. D.: Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature 515, S. 577 - 581 (2017)
  33. Geltink, R. I. K.; O’Sullivan, D.; Corrado, M.; Bremser, A.; Buck, M. D.; Buescher, J. M.; Firat, E.; Zhu, X.; Niedermann, G.; Caputa, G. et al.; Kelly, B.; Warthorst, U.; Rensing-Ehl, A.; Kyle, R. L.; Vandersarren, L.; Curtis, J. D.; Patterson, A. E.; Lawless, S.; Grzes, K.; Qiu, J.; Sanin, D. E.; Kretz, O.; Huber, T. B.; Janssens, S.; Lambrecht, B. N.; Rambold, A.; Pearce, E. J.; Pearce, E. L.: Mitochondrial Priming by CD28. Cell 171, S. 385 - 397 (2017)
  34. Puleston, D.; Mateo, V.; Pearce, E. L.: Ancillary Activity: Beyond Core Metabolism in Immune Cells. Cell Metabolism 26, S. 131 - 141 (2017)
  35. Buck, M.; Sowell, R. T.; Kaech, S. M.; Pearce, E. L.: Metabolic Instruction of Immunity. Cell, S. 570 - 586 (2017)
  36. Klein-Geltink, R.; O'Sullivan, D.; Pearce, E. L.: Caught in the cROssfire: GSH Controls T Cell Metabolic Reprogramming. Immunity 46, S. 525 - 527 (2017)
  37. 2016
    Huang, S. C.-C.; Smith, A. M.; Everts, B.; Colonna, M.; Pearce, E. L.; Schilling, J. D.; Pearce, E. J.: Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis is Essential for Macrophage Alternative Activation. Immunity 45, S. 817 - 830 (2016)
  38. O'Sullivan, D.; Kelly, B.; Pearce, E. L.: When Hexokinase Gets that NAG-ing Feeling. Cell Metabolism 24, S. 198 - 200 (2016)
  39. Lam, W. Y.; Becker, A. M.; Kennerly, K. M.; Wong, R.; Curtis, J. D.; Llufrio, E. M.; McCommis, K. S.; Fahrmann, J.; Pizzato, H. A.; Nunley, R. M. et al.; Lee, J.; Wolfgang, M. J.; Patti, G. J.; Finck, B. N.; Pearce, E. L.; Bhattacharya, D.: Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells. Immunity 45, S. 60 - 73 (2016)
  40. Buck, M. D.; O’Sullivan, D.; Geltink, R. I. K.; Curtis, J. D.; Chang, C.-H.; Sanin, D. E.; Qiu, J.; Kretz, O.; Braas, D.; van der Windt, G. J.W. et al.; Chen, Q.; Huang, S. C.-C.; O’Neill, C. M.; Edelson, B. T.; Pearce, E. J.; Sesaki, H.; Huber, T. B.; Rambold, A.; Pearce, E. L.: Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming. Cell 166, S. 63 - 76 (2016)
  41. Kaiko, G. E.; Ryu, S. H.; Koues, O. I.; Collins, P. L.; Solnica-Krezel, L.; Pearce, E. J.; Pearce, E. L.; Oltz, E. M.; Stappenbeck, T. S.: The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites. Cell 167, S. 1708 - 1720 (2016)
  42. Monticelli, L. A.; Buck, M. D.; Flamar, A.-L.; Saenz, S. A.; Wojno, E. D. T.; Yudanin, N. A.; Osborne, L. C.; Hepworth, M. R.; Tran, S. V.; Rodewald, H.-R. et al.; Shah, H.; Cross, J. R.; Diamond, J. M.; Cantu, E.; Christie, J. D.; Pearce, E. L.; Artis, D.: Arginase 1 is an innate lymphoid-cell intrinisic metabolic checkpoint controlling type 2 inflammation. Nature Immunology 17, S. 656 - 665 (2016)
  43. Chang, C.-H.; Pearce, E. L.: Emerging concepts of T cell metabolism as a target of immunotherapy. Nature Immunology 17, S. 364 - 368 (2016)
  44. van der Windt, G. J.W.; Chang, C.; Pearce, E. L.: Measuring Bioenergetics in T Cells Using a Seahorse Extracellular Flux Analyzer. Current Protocols in Immunology 113, S. 16B1.3 - 16B.14 (2016)
  45. 2015
    Chang, C.-H.; Qiu, J.; O'Sullivan, D.; Buck, M.; Noguchi, T.; Curtis, J. D.; Chen, Q.; Gindin, M.; Gubin, M. M.; van der Windt, G. J.W. et al.; Tonc, E.; Schreiber, R. D.; Pearce, E. J.; Pearce, E. L.: Metabolic Competition in the Tumor Microenvironment is a Driver of Cancer Progression. Cell 162, S. 1229 - 1241 (2015)
  46. Buck, M. D.; O'Sullivan, D.; Pearce, E. L.: T cell metabolism drives immunity. Journal of Experimental Medicine 212, S. 1345 - 1360 (2015)
  47. O'Sullivan, D.; Pearce, E. L.: Immunology, Expanding the roles of metabolism in T cells. Science 348, S. 976 - 977 (2015)
  48. O'Sullivan, D.; Pearce, E. L.: Targeting T cell metabolism for therapy. Trends in Immunology 36, S. 71 - 80 (2015)
  49. Blagih, J.; Coulombe, F.; Vincent, E. E.; Dupuy, F.; Galicia-Vázquez, G.; Yurchenko, E.; Raissi, T. C.; van der Windt, G. J.W.; Viollet, B.; Pearce, E. L. et al.; Pelletier, J.; Piccirillo, C. A.; Krawczyk, C. M.; Divangahi, M.; Jones, R. G.: The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vitro. Immunity 42, S. 41 - 54 (2015)
  50. 2014
    Xu, X.; Araki, K.; Li, S.; Han, J.-H.; Ye, L.; Tan, W. G.; Konieczny, B. T.; Bruinsma, M. W.; Martinez, J.; Pearce, E. L. et al.; Green, D. R.; Jones, D. P.; Virgin, H. W.; Ahmed, R.; Xu, X.; Araki, K.; Li, S.; Han, J.-H.; Ye, L.; Tan, W. G.; Konieczny, B. T.; Bruinsma, M. W.; Martinez, J.; Pearce, E. L.; Green, D. R.; Jones, D. P.; Ahmed, R.: Autophagy is essential for effector CD8+ T cell survival and memory formation. Nature Immunology 15, S. 1152 - 1161 (2014)
  51. O'Sullivan, D.; Pearce, E. L.: Fatty acid sysnthesis tips the TH17-Treg cell balance. Nature Medicine 20, S. 1235 - 1236 (2014)
  52. Walsh, M. C.; Pearce, E. L.; Cejas, P. J.; Lee, J.; Wang, L.-S.; Choi, Y.: IL-18 synergivzes with IL-7 to drive slow proliferation of naive CD8 T cells by costimulating self-peptide-mediated TCR signals. The Journal of Immunology 193, S. 3992 - 4001 (2014)
  53. Amiel, E.; Everts, B.; Fritz, D.; Beauchamp, S.; Ge, B.; Pearce, E. L.; Pearce, E. J.: Mechanistic target of rapamycin inhition extend cellular lifespan in dendritic cells by preserving mitochondrial function. The Journal of Immunology 193, S. 2821 - 2830 (2014)
  54. Chou, C.; Pinto, A. K.; Jonathen, C.; Persaud, S. P.; Cella, M.; Lin, C.-C.; Edelson, B. T.; Allen, P. M.; Colonna, M.; Pearce, E. L. et al.; Diamond, M. S.; Egawa, T.: c-Myc-induced transcription factor AP4 is requeired for host protection mediated by CD8+ T Cells. Nature Immunology 15, S. 884 - 893 (2014)
  55. Huang, S. C.-C.; Everts, B.; Ivanova, Y.; O'Sullivan, D.; Nascimento, M.; Smith, A. M.; Beatty, W.; Love-Gregory, L.; Lam, W. Y.; O'Neill, C. M. et al.; Yan, C.; Du, H.; Abumrad, N. A.; Urban, J. F. J.; Artyomov, M. N.; Pearce, E. J.; Pearce, E. L.: Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nature Immunology 15, S. 846 - 855 (2014)
  56. O'Sullivan, D.; van der Windt, G. J.W.; Huang, S. C.-C.; Curtis , J.; Chang, C.-H.; Buck, M. D.; Qiu, J.; Smith, A. M.; Lam, W. Y.; DiPlato, L. M. et al.; Hsu, F.-F.; Birnbaum, M. J.; Pearce, E. J.; Pearce, E. L.: Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity 41, S. 75 - 88 (2014)
  57. Everts, B.; Amiel, E.; Huang, S. C.-C.; Smith, A. M.; Chang, C.-H.; Lam, W. Y.; Redmann, V.; Freitas, T. C.; Blagih, J.; van der Windt, G. J. W. et al.; Artyomov, M. N.; Jones, R. G.; Pearce, E. L.; Pearce, E. J.: TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation. Nature Immunology 15, S. 323 - 332 (2014)
  58. 2013
    Pearce, E. L.; Poffenberger, M. C.; Chang, C.-H.; Jones, R. G.: Fueling immunity: insights into metabolism and lymphocyte function. Science 342, S. 1242454 (2013)
  59. van der Windt, G. J. W.; O’Sullivan, D.; Everts, B.; Huang, S. C.-C.; Buck, M. D.; Curtis, J. D.; Chang, C.-H.; Smith, A. M.; Ai, T.; Faubert, B. et al.; Jones, R. G.; Pearce, E. J.; Pearce, E. L.: CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability. Proceedings of the National Academy of Sciences of the United States of America 153, S. 1239 - 1259 (2013)
  60. Chang, C.-H.; Curtis, J. D.; Maggi Jr., L. B.; Faubert, B.; Villarino, A. V.; O’Sullivan, D.; Huang, S. C.-C.; van der Windt, G. J.W.; Blagih, J.; Qiu, J. et al.; Weber, J. D.; Pearce, E. J.; Jones, R. G.; Pearce, E. L.: Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 153, S. 1239 - 1251 (2013)
  61. Pearce, E. L.; Pearce, E. J.: Metabolic pathways in immune cell activation and quiscence. Immunity 38, S. 633 - 643 (2013)
  62. 2012
    van der Windt , G. J. W.; Pearce, E. L.: Metabolic switching and fuel choice during T-cell differentiation and memory development. Immunological Reviews 249, S. 27 - 42 (2012)
  63. Amiel, E.; Everts, B.; Freitas, T. C.; King, I. L.; Curtis, J. D.; Pearce, E. L.; Pearce, E. J.: Inhibition of mechanistic target of repamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice. The Journal of Immunology 189, S. 2151 - 2158 (2012)
  64. Everts, B.; Amiel, E.; van der Windt, G. J. W.; Freitas, T. C.; Chott, R.; Yarasheski, K. E.; Pearce, E. L.; Pearce, E. J.: Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. Blood 120, S. 1422 - 1431 (2012)
  65. Cejas, P. J.; Walsh, M. C.; Pearce, E. L.; Han, D.; Harms, G. M.; Artis, D.; Turka, L. A.; Choi, Y.: TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2. Blood 115, S. 4750 - 4757 (2012)
  66. van der Windt, G. J.W.; Everts, B.; Chang, C.-H.; Curtis, J. D.; Freitas, T. C.; Amiel, E.; Pearce, E. J.; Pearce, E. L.: Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity 36, S. 68 - 78 (2012)
  67. Huang, S. C.-C.; Freitas, T. C.; Amiel, E.; Everts, B.; Pearce, E. L.; Lok, J. B.; Pearce, E. J.: Fatty acid oxidation is essential for egg production by the parasitic flatworm Schistosoma mansoni. PLoS Pathogens 8, S. e1002996 (2012)
  68. 2010
    Pearce, E. L.: Metabolism in T cell activation and differentiation. Current Opinion in Immunology 22, S. 314 - 320 (2010)
 
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