Innate lymphoid cells (ILCs) have been discovered as the innate counter-parts of T-cells. There are three major ILC subtypes with different functions and tissue-specific distributions. Although they encompass only a couple of thousand cells in some tissues, ILCs are important regulators of tissue immunity, inflammation and homeostasis.
How is the heterogeneity of ILC populations achieved, regulated during steady state and inflammatory conditions and which aberrations can result in diseases? These are questions I will tackle during my PhD research.