Abu Safyan

from Charsadda, Pakistan
IMPRS fellow since April 2016 in Pyrowolakis lab
Research interestsBone morphogenetic proteins (BMPs) are multifunctional polypeptides that control numerous cellular and developmental processes. Many diseases, including developmental defects and cancer are associated with dysfunctional TGF-β/BMP signaling. BMP receptors destabilization by endocytosis has been involved in proper regulation and function of BMP signaling in multiple contexts. My project focuses on identification of the endocytic machinery involved in destabilization of BMP receptors using the Drosophila wing imaginal disc as a model. Additionally, I am investigating the interactions of extracellular components with BMP receptors and the impact of such interactions on receptor endocytosis.

Research interests
Bone morphogenetic proteins (BMPs) are multifunctional polypeptides that control numerous cellular and developmental processes. Many diseases, including developmental defects and cancer are associated with dysfunctional TGF-β/BMP signaling. BMP receptors destabilization by endocytosis has been involved in proper regulation and function of BMP signaling in multiple contexts. My project focuses on identification of the endocytic machinery involved in destabilization of BMP receptors using the Drosophila wing imaginal disc as a model. Additionally, I am investigating the interactions of extracellular components with BMP receptors and the impact of such interactions on receptor endocytosis.
 
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