Hematopoiesis is a tightly regulated process and indispensable for the proper maintenance of blood homeostasis. Hematopoietic stem cells (HSCs) sit atop of the hematopoietic tree and guarantee the production of blood cells upon stress responses. HSCs are highly quiescent and retain the highest self-renewal capacity. Dysregulation of this process might cause aberrant hematopoiesis. The regulators of this quiescent state include intrinsic pathways as well as soluble components from the bone marrow niche, but still, those are poorly understood. During my PhD thesis I aim to study the regulation of hematopoietic stem cell quiescence.
Schönberger K, Cabezas-Wallscheid N (2017). Vitamin C: C-ing a New Way to Fight Leukemia. Cell Stem Cell 2017 Nov 2; 21(5):561-563.