Dormant hematopoietic stem cells (dHSCs) are atop the hematopoietic hierarchy and are identified through long-term label retaining assays. Technical limitations have prevented the identification of a dormant HSC population in humans. Recently, Cabezas-Wallscheid et al. identified Gprc5c as a surface receptor marking dormant mouse HSC. In the context of human HSCs, transcriptome data has shown that GPRC5C may also be a potential marker for human HSC dormancy. We aim to identify the first dormant human HSC population using GPRC5C as a potential surface marker.