Yi Hsuan Lo
from Taiwan

IMPRS doctoral researcher since September 2018 in Jenuwein lab
Research interestsMajor satellite repeats (MSRs) are enriched at pericentromeric heterochromatin in the mouse genome consisting of large tandemly repeating AT-rich sequences harboring transcription factor binding sites. They are the primary chromatin targets of Suv39h enzymes and are marked with H3K9me3 in mouse embryonic stem cells (mESCs) and fibroblasts. Although many genetic and epigenetic principles of heterochromatin are well documented, what role MSR repetitive DNA sequences plays in the de novoformation of heterochromatin in mESCs, at pericentromeric and intergenic sites in the mouse genome remains elusive. The aim of my PhD project is to investigate the role of MSR repetitive DNA sequences in the de novo establishment of heterochromatin in mESCs and the underlying repressive mechanisms of intergenic MSR.​

Research interests
Major satellite repeats (MSRs) are enriched at pericentromeric heterochromatin in the mouse genome consisting of large tandemly repeating AT-rich sequences harboring transcription factor binding sites. They are the primary chromatin targets of Suv39h enzymes and are marked with H3K9me3 in mouse embryonic stem cells (mESCs) and fibroblasts. Although many genetic and epigenetic principles of heterochromatin are well documented, what role MSR repetitive DNA sequences plays in the de novoformation of heterochromatin in mESCs, at pericentromeric and intergenic sites in the mouse genome remains elusive. The aim of my PhD project is to investigate the role of MSR repetitive DNA sequences in the de novo establishment of heterochromatin in mESCs and the underlying repressive mechanisms of intergenic MSR.​
 
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