Postdoctoral Position (Experimental Quantitative Single-Cell Biology) (m/f/d)

Max Planck Institute of Immunobiology and Epigenetics, Freiburg

Developmental and Evolutionary Biology & Genetics Immunobiology and Infection Biology & Medicine

Type of Job

Scientist

Postdoctoral Position (m/f/d) Experimental Quantitative Single-Cell Biology

Job offer from June 17, 2020

The Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany, has an opening for an ERC funded postdoc position (m/f/d) in quantitative single cell biology for an initial period of two years. The position is available in the group of Dominic Grün (https://www.ie-freiburg.mpg.de/gruen). We are studying cell fate decision in multilineage systems with the aim to decipher the molecular control of cell fate choice. We investigate the role of cell extrinsic signals in the control of cell fate decision by integrating cutting-edge single-cell sequencing of different modalities and high-resolution spatial imaging approaches. The proposed project aims at characterizing the spatial architecture of the bone marrow microenvironment at single-cell resolution in healthy tissue and its perturbations upon the emergence of leukemia. The position offers the opportunity to integrate state-of-the-art single-cell sequencing methods and high-resolution genome-scale spatial imaging methods (seqFISH) towards revealing the dynamics of hematopoietic niches during leukemia development. The project will combine the analysis of mouse models and human tissue samples

The Max Planck Institute of Immunobiology and Epigenetics (MPI-IE) in Freiburg, Germany is an interdisciplinary research institution that conducts basic research in two key areas of modern biology: Immunobiology and Epigenetics. Central questions address the molecular basis of cell type identities, as they are regulated during immune cell differentiation, metabolic response and epigenetic chromatin adaptation.

Your tasks:

You will characterize the bone marrow hematopoietic niche by single-cell sequencing (RNA, open chromatin) and highly multiplexed single-molecule FISH (seqFISH) in mouse leukemia models and human bone marrow samples. You will learn the quantitative analysis of these single-cell data with the help of machine learning and statistical modeling techniques established in our lab.

Your qualifications:

  • PhD in life science, biology, natural science, or comparable,
  • Strong background in basic molecular biology techniques,
  • Proficiency of fluorescence microscopy and tissue handling (cryo-sectioning),
  • Proficiency in cell purification by flow cytometry,
  • Background in (single-cell) omics techniques is a plus,
  • Specific knowledge of hematopoiesis is a plus,
  • Profound interest in stem cell differentiation,
  • At least one first author paper in an international peer-reviewed journal,
  • fluency in English

We are looking for a motivated team player with strong communication skills and the desire to work in a dynamic environment. Your desire to understand biological problems is a must, and prior experience in the field stem cell differentiation and hematopoiesis is a strong plus.

We offer:

Based within close vicinity to both France and Switzerland, our institute hosts a vibrant community of international researchers and many state-of-the-art facilities (e.g. a modern deep-sequencing unit and a powerful data center). Salaries will be based on previous experience according to TVöD guidelines.

Handicapped applicants with equal qualifications will be given preferential treatment. The Max Planck Society seeks to increase the number of women in areas, where they are underrepresented, and therefore explicitly encourages women to apply. The Max Planck Society strives for gender and diversity equality. We welcome applications from all backgrounds. A childcare facility is directly attached to the institute.


Application deadline:

Have we sparked your interest? Please submit your complete application, including a CV via our online application portal until 22nd of July 2020.

Max Planck Institute of Immunobiology and Epigenetics
Stübeweg 51
79108 Freiburg
Germany

 
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