Metabolism in hematology

How technological advances are reshaping our understanding of metabolism in hematology and cancer research.

July 29, 2025

Technological advances are reshaping our understanding of metabolism in hematology and cancer research. In this two-part HemaSphere podcast  Prof. Dr. Petya Apostolova (former Pearce lab), and Dr. Jörg Büscher (MPI-IE metabolomics facility) discuss the role of metabolism, challenges in metabolomics, and future research directions, particularly regarding acute myeloid leukemia (AML). The importance of integrating multiomics approaches and the potential of spatial metabolomics are emphasized.

Listen to both episodes here and subscribe to the hemasphere podcast.

In this episode of the HemaSphere podcast, Dr Jörg Büscher (MPI-IE) and Prof Dr Petya Apostolova discuss the critical role of metabolism in cellular function, particularly in the context of hematology and cancer research. 

Part 1 - Metabolism in hematology

In this episode of the HemaSphere podcast, Dr Jörg Büscher (MPI-IE) and Prof Dr Petya Apostolova discuss the critical role of metabolism in cellular function, particularly in the context of hematology and cancer research. 
https://www.youtube.com/watch?v=-GHI_E98IdA
In this episode, hemasphere host Charles De Bock engages with Prof Dr Petya Apostolova and Dr Jörg Büscher to explore the intricate relationship between metabolism and hematology, particularly focusing on AML.

Part 2 - Metabolism in hematology

In this episode, hemasphere host Charles De Bock engages with Prof Dr Petya Apostolova and Dr Jörg Büscher to explore the intricate relationship between metabolism and hematology, particularly focusing on AML.
https://www.youtube.com/watch?v=2cEVK396gSM

From the show notes

In this 2-part episode of the HemaSphere podcast, host Dr Charles de Bock and guests Dr Jörg Büscher (MPI-IE) and Prof Dr Petya Apostolova (University Basel) discuss the critical role of metabolism in cellular function, particularly in the context of hematology and cancer research. The discussion highlights the technological advancements in metabolic analysis and their impact on understanding cellular metabolism. They also explore the challenges and future directions in metabolism research and the potential of spatial metabolomics.

In this second part, Dr Charles De Bock engages with Prof Dr Petya Apostolova and Dr Jörg Büscher to explore the intricate relationship between metabolism and hematology, particularly focusing on #AML. They discuss the challenges and advancements in metabolomics, the importance of integrating multi-omics approaches, and the future directions of research in this field. The conversation highlights the need for a deeper understanding of metabolic pathways and their implications for cancer treatment, emphasizing the significance of context in cellular behavior and the potential of spatial metabolomics.

You can find the referenced review article, in full and open access, on the HemaSphere or here.

Haring E, Buescher JM, Apostolova P (2025)
Metabolism in hematology: Technological advances open new perspectives on disease biology and treatment.
Hemasphere 9(5), e70134. 

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