Research interests
The early embryonic development is mainly driven by maternally loaded RNAs and proteins. As the development progresses, the stored stockpile is degraded and replaced by zygotically synthesized biomolecules. The process is crucial in development and referred to as maternal to zygotic transition. While there are plenty of studies available on maternal RNA kinetics in early development, there are fewer studies on maternal protein landscape in embryogenesis. It is known that maternal protein degradation is slower than degradation of maternally loaded RNA with a large impact on specificity, timing and likely also localization of the degradation. My thesis aims to resolve the maternal proteome kinetics as the development progresses. We then aim to study if and to what extent maternal proteins play a role in the cell type specification events during development.
