Genome Biology
Department
The Department of Genome Biology, led by Marieke Oudelaar, investigates the interplay between 3D genome organization and the regulation of gene expression. Our overarching goals are to define the 3D organization of eukaryotic genomes at high resolution across scales and biological contexts, to identify the molecular mechanisms that establish and maintain these 3D genome structures, and to determine how gene expression is regulated within this 3D nuclear context. To address these goals, we develop and apply cutting-edge technologies to study genome folding and gene regulation in dynamic cellular states and minimal cell-free systems. Our work integrates genomics, imaging, proteomics, biochemistry, and computational biology, with the ultimate aim of developing a mechanistic and holistic understanding of 3D genome organization and gene regulation.
