MPS: Eugene Kim - tba.

The Kim lab studies the molecular mechanisms governing 3D genome organization: how chromatins are folded and twisted, and how these topologies affect genome functions. To this end, the lab employ single-molecule fluorescence imaging, single-molecule force spectroscopy, and correlative light and electron microscopy techniques to probe and interrogate individual molecules in vitro. By studying individual biochemical processes that constitute genome packaging at high spatiotemporal resolution, the lab wants to extract the universal principles that underlie chromosome organization across all forms of life. Among other things, she discovered how several such condensins work together to form the structure of chromosomes without colliding and interfering with each other.