MPS: Ming-Kang Lee - Temporal degradation of PRC2 uncovers specific developmental dependencies

Ming-Kang Lee from the Max Planck Institute for Molecular Genetics in Berlin is a senior postdoc in the lab of Alex Meissner. His current work focusses on the role of Polycomb repressive complex 2 (PRC2) during embryonic development.

Polycomb repressive complex 2 (PRC2) is essential for gene silencing, but how its loss translates into developmental failure remains difficult to address in vivo. By integrating rapid PRC2 degradation within a scalable embryoid model, we demonstrated that PRC2 loss triggers an unexpected ectopic expression of anterior and lateral lineage genes. Additionally, we showed that while developmental genes consistently require PRC2 activity, pluripotency-associated genes are only responsive under early PRC2 depletion. Together, our results provided the mechanistic framework of dynamic PRC2 dependencies at temporal, lineage and gene-specific resolution.

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