Suzan Saidin

Doktorand/in

Forschungsinteressen

The tissue resident memory (TRM) cells reside in non-lymphoid tissues where many of these organs, such as the skin and intestinal tract, are constantly exposed to external stimuli. TRMcells are therefore an essential part of tissue immunity for their localization enables more immediate and localized adaptive immune responses in comparison to circulating memory cells. While the signals required to reproduce canonical memory and effector T cell phenotypes in vitro are well-studied, the signals required to generate TRMcells in vitro are still unknown. My project seeks to establish culture systems that enable in vitro generation of CD8+TRMcells. Establishing such culture conditions will not only provide a powerful tool for investigating TRMcell biology, but also potentially benefit therapeutic strategies.

Vita

  • PhD Student, International Max Planck Research School for Immunobiology, Epigenetics and Metabolism, Germany (2018-present)

  • Research Associate, Translational Immunology Institute, Singapore Health Services Pte Ltd (2014-2018)

  • MSc Thesis “Regulation Of Intestinal Inflammation By Mitogen-Activated Protein Kinase Phosphatase-3”, National University of Singapore (2011-2014)

  • Research Assistant, National University of Singapore (2008-2010)

  • Bachelor of Science (Biotechnology), Second Class Honours, Monash University Malaysia (2004-2008)


Selected publications

Paleja B, Low AHL, Kumar P, Saidin S,Lajam A, Nur Hazirah S, Chua C, Li Yun L, and Albani S. (2020): Systemic Sclerosis Perturbs the Architecture of the Immunome. Front Immunol 11, 1602.

DOI:10.3389/fimmu.2020.01602

Rossetti M, Spreafico R, Saidin S,Chua C, Moshref M, Leong JY, Tan YK, Thumboo J, van Loosdregt J, and Albani S. (2015): Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region. J Immunol 194, pp. 113-124.

DOI:10.4049/jimmunol.1401145

Chee JL, Saidin S,Lane DP, Leong SM, Noll JE, Neilsen PM, Phua YT, Gabra H, and Lim TM. (2013): Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9. Cell Cycle 12, pp. 278-288. DOI:10.4161/cc.23054


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