Head of Department

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Dr. Asifa Akhtar
Senior Group Leader and Managing Director
Phone:+49 761 5108 565

Lab Asifa Akhtar

Assistant: Linda Schmidl phone: +49 761 5108 564 Email: schmidl@ie-freiburg.mpg.de

Further Group Leader

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Dr. Nicola Iovino
Group Leader
Phone:+49 761 5108 779

Lab Nicola Iovino

Department of Chromatin Regulation

Chromatin Regulation

The Department of Chromatin Regulation is headed by Asifa Akhtar. The major research goal of this department is to study the chromatin and epigenetic mechanisms underlying gene regulation using dosage compensation in Drosophila as a powerful model system to study chromatin regulation at individual gene level as well from a chromosomal perspective. We are addressing how the dosage compensation complex, composed of RNA and proteins (the MSL complex) is specifically targeted to the X chromosome. Furthermore, we are investigating whether chromosome organization and nuclear architecture contribute to transcription activity and how this influences X chromosomal regulation. Ultimately, we would like to understand the molecular mechanism by which dosage compensation modulates X chromosomal transcriptional output. In order to achieve that, we are employing biochemical, genetic, genomic and bioinformatics methodologies to generate a holistic model of dosage compensation.

 
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