Group Leader

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Prof. Dr. Thomas Jenuwein
Senior Group Leader & Director
Phone:+49 761 5108 785

Lab Thomas Jenuwein

Assistant: Marcela Mare Phone: +49 761 5108 574 Email: mare@ie-freiburg.mpg.de

Selected Publications

1.
Bulut-Karslioglu A, De La Rosa-Velázquez IA, Ramirez F, Barenboim M, Onishi-Seebacher M, Arand J, Galán C, Winter GE, Engist B, Gerle B, O'Sullivan RJ, Martens JH, Walter J, Manke T, Lachner M, Jenuwein T. (2014)

Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells.

2.
Bulut-Karslioglu A, Perrera V, Scaranaro M, de la Rosa-Velazquez IA, van de Nobelen S, Shukeir N, Popow J, Gerle B, Opravil S, Pagani M, Meidhof S, Brabletz T, Manke T, Lachner M, Jenuwein T. (2012)
A transcription factor-based mechanism for mouse heterochromatin formation.
3.
Pinheiro I, Margueron R, Shukeir N, Eisold M, Fritzsch C, Richter FM, Mittler G, Genoud C, Goyama S, Kurokawa M, Son J, Reinberg D, Lachner M, Jenuwein T. (2012)
Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity.
4.
Fodor BD, Shukeir N, Reuter G, Jenuwein T. (2010)
Mammalian Su(var) genes in chromatin control.
5.
Feng W, Yonezawa M, Ye J, Jenuwein T, Grummt I. (2010).
PHF8 activates transcription of rRNA genes by binding to trimethylated H3K4 and demethylating H3K9me1/2

Laboratory Thomas Jenuwein

Laboratory Thomas Jenuwein

Epigenetic mechanisms control eukaryotic development beyond DNA-stored information. There are many pathways, such as DNA methylation, nucleosome remodelling, histone modifications, exchange of histone variants and non-coding RNAs that together contribute to differences of the chromatin template. In particular, the great diversity of covalent histone tail modifications has been proposed to reflect an index ('histone code') that can stabilize distinct proliferative and developmental options. We discovered the first histone lysine methyltransferase and then showed that histone lysine methylation represents a central epigenetic modification in eukaryotic chromatin. We are continuing with our analyses on histone lysine methylation to further dissect epigenetic gene regulation and to identify molecular pathways that initiate and maintain heterochromatic domains in mammalian chromatin.

 
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