Group Leader

Prof. Dr. Michael Reth
Senior University Group Leader & Adjunct Scientific Member (MPI-IE/Uni)
Phone:+49 761 5108 421

Lab Michael Reth

Birgit Jäger / Miriam Vitt
Assistants to Michael Reth
Phone:+49 761 5108 420Fax:+49 761 5108 423

Selected Publications

Kläsener K, Maity PC, Hobeika E, Yang J, Reth M.
B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk.
Reth, M. (2013)
Matching cellular dimensions with molecular sizes.
Thedieck, K., B. Holzwarth, et al. (2013)
Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells.
Yang, J. and M. Reth (2010)
Oligomeric organization of the B-cell antigen receptor on resting cells.
Yang, J. and M. Reth (2010).
The dissociation activation model of B cell antigen receptor triggering

Laboratory Michael Reth

Laboratory Michael Reth

Research in the Department of Molecular Immunology seeks a better understanding of the organisation and regulation of receptors and intracellular signalling pathways in normal and diseased lymphocytes. Our research is largely focused on the development and function of B lymphocytes. We have proposed a new model for the structure and activation of the B cell antigen receptor (BCR) and have discovered new signalling components in activated B cells. We also developed techniques for a more profound study of signalling mechanism in resting and activated B cells. Several of our findings have contributed to a better understanding of human diseases such as leukemias and autoimmunity. Furthermore, we are among the first to adapt synthetic biology approaches for studying signalling in mammalian cells. In a collaboration between the University of Freiburg and the MPI, the department also organizes an advanced study program for molecular immunology. This popular program started in 1997 and attracts students both from Freiburg and from other Universities.

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