Group Leader

Dr. J. Andrew Pospisilik
Dr. J. Andrew Pospisilik
Group Leader
Phone:+49 761 5108-757

Lab Andrew Pospisilik


Who am I not? – Video abstract: Pospisilik et al. 2016 – Cell 163 (3), 353-364.

We are actually a lot closer to the bugs than we thought, at least epigenetically. Watch the video abstract on the newly discovered regulatory, epigenetic switch, which causes individuals with identical genetic material, such as monozygotic twins, to either be lean or obese.

Pospisilik et al (2016): Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity, Cell 164 (3), 353-364, 28 January 2016.

Selected Publications

Lu TT, Heyne S, Dror E, Casas E, Leonhardt L, Boenke T, Yang CH, Sagar, Arrigoni L, Dalgaard K, Teperino R, Enders L, Selvaraj M, Ruf M, Raja SJ, Xie H, Boenisch U, Orkin SH, Lynn FC, Hoffman BG, Grün D, Vavouri T, Lempradl AM, Pospisilik JA (2018)
The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes.
Dalgaard K, Landgraf K, Heyne S, Lempradl A, Longinotto J, Gossens K, Ruf M, Orthofer M, Strogantsev R, Selvaraj M, Lu TT, Casas E, Teperino R, Surani MA, Zvetkova I, Rimmington D, Tung YC, Lam B, Larder R, Yeo GS, O'Rahilly S, Vavouri T, Whitelaw E, Penninger JM, Jenuwein T, Cheung CL, Ferguson-Smith AC, Coll AP, Körner A, Pospisilik JA (2016)
Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity
Ost A, Lempradl A, Casas E, Weigert M, Tiko T, Deniz M, Pantano L, Boenisch U, Itskov PM, Stoeckius M, Ruf M, Rajewsky N, Reuter G, Iovino N, Ribeiro C, Alenius M, Heyne S, Vavouri T, Pospisilik JA. (2014)
Paternal diet defines offspring chromatin state and intergenerational obesity.
Jais A, Einwallner E, Sharif O, Gossens K, Lu TT, Soyal SM, Medgyesi D, Neureiter D, Paier-Pourani J, Dalgaard K, Duvigneau JC, Lindroos-Christensen J, Zapf TC, Amann S, Saluzzo S, Jantscher F, Stiedl P, Todoric J, Martins R, Oberkofler H, Müller S, Hauser-Kronberger C, Kenner L, Casanova E, Sutterlüty-Fall H, Bilban M, Miller K, Kozlov AV, Krempler F, Knapp S, Lumeng CN, Patsch W, Wagner O, Pospisilik JA, Esterbauer H. (2014)
Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man.
Teperino R, Amann S, Bayer M, McGee SL, Loipetzberger A, Connor T, Jaeger C, Kammerer B, Winter L, Wiche G, Dalgaard K, Selvaraj M, Gaster M, Lee-Young RS, Febbraio MA, Knauf C, Cani PD, Aberger F, Penninger JM, Pospisilik JA, Esterbauer H. (2012)
Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat.

Laboratory J. Andrew Pospisilik

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Laboratory J. Andrew Pospisilik

Epigenetic control of phenotypic variation and disease

We aim to answer the question, “Who could I have been?”. Our lab aims to challenge dogmas in understanding the mechanisms underpinning disease and evolution. Current estimates place the prevalence of diabetes, neurodegeneration, cancer and obesity beyond 1 billion individuals worldwide. These represent the world’s chief economic and health care challenges of the day. While studies have established elegant genetic frameworks for our current understanding of these complex disorders the contribution of a number of critical regulatory layers, in particular developmental and epigenetic regulation, remains poorly understood.

Our lab is interested in understanding epigenetic regulatory systems that contribute to phenotypic variation and thus to disease susceptibility. These paradigms include, among others, metabolic- and signaling-mediated changes to post-translational modifications of histones, non-coding RNAs, and modifiers of chromatin stability such as the Polycomb-Trithorax Groups. What is clear at present is that these epigenetic effectors play a critical role in defining set-points for entire functional gene sets; the fundamental outstanding question we are interested in is how these epigenetic cues influence the susceptibility and development of human disease. Our efforts are split into two avenues

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