Head of Department

Dr. Asifa Akhtar
Dr. Asifa Akhtar
Senior Group Leader and Director

Lab Asifa Akhtar

Assistant – phone: +49 761 5108-564 Email: akhtarassistant@ie-freiburg.mpg.de

Further Group Leader

Dr. Nicola Iovino
Dr. Nicola Iovino
Group Leader

Lab Nicola Iovino

Department of Chromatin Regulation

Chromatin Regulation

The Department of Chromatin Regulation is headed by Asifa Akhtar. The major research goal of this department is to study the chromatin and epigenetic mechanisms underlying gene regulation using dosage compensation in Drosophila as a powerful model system to study chromatin regulation at individual gene level as well from a chromosomal perspective. We are addressing how the dosage compensation complex, composed of RNA and proteins (the MSL complex) is specifically targeted to the X chromosome. Furthermore, we are investigating whether chromosome organization and nuclear architecture contribute to transcription activity and how this influences X chromosomal regulation. Ultimately, we would like to understand the molecular mechanism by which dosage compensation modulates X chromosomal transcriptional output. In order to achieve that, we are employing biochemical, genetic, genomic and bioinformatics methodologies to generate a holistic model of dosage compensation.

loading content
Go to Editor View