Deep Sequencing Facility

Deep Sequencing Facility

We are experts in genomics, focusing on the development of sequencing technologies. We provide cutting-edge technology that allows researchers to work on innovative, sophisticated projects.

Standardizing pre-analytical sample preparation is a key aspect of our work. For this purpose, we invest massively in protocol development and automation. As a central sequencing platform, we rely on instrumentation from the company Illumina (NovaSeq, NextSeq, MiSeq) as well as Oxford Nanopore (GridION).

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Together with the Bioinformatics Facility, we ensure high-quality data production and continuously update our workflows. Advising on experimental settings and training is a very important aspect of our work. Especially young researchers profit at the beginning of their career from hands-on courses using specialized, sophisticated equipment.

Selected publications

Arrigoni L, Ferrari F, Weller J, Bella C, Bönisch U, Manke T (2020)
AutoRELACS: automated generation and analysis of ultra-parallel ChIP-seq
Scientific Reports 10(1), 12400.
Source
DOI
Arrigoni L, Al-Hasani H, Ramírez F, Panzeri I, Ryan DP, Santacruz D, Kress N, Pospisilik JA, Bönisch U, Manke T (2018)
RELACS nuclei barcoding enables high-throughput ChIP-seq
Communications Biology 1, 214.
Source
DOI
Anatskiy E, Ryan DP, Grüning BA, Arrigoni L, Manke T, Bönisch U (2019)
Parkour LIMS: high-quality sample preparation in next generation sequencing
Bioinformatics 35(8), 1422–1424.
Source
DOI
Stunnenberg, HG, The International Human Epigenome Consortium (2016)
The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery
Cell 167(5), 1145–1149.
Source
DOI
Arrigoni L, Richter AS, Betancourt E, Bruder K, Diehl S, Manke T and Bönisch U (2016)
Standardizing chromatin research: a simple and universal method for ChIP-seq
Nucleic Acids Research 44(7), e67.
Source
DOI
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