Deep Sequencing Facility

Deep Sequencing Facility

We are experts in genomics, focusing on development of sequencing technologies. We provide cutting-edge technology that allows researchers to work on innovative, sophisticated projects.

Standardizing pre-analytical sample preparation is key aspect of our work. To this, we invest massively in protocol development and automation. As central sequencing platform, we rely on instrumentation from the company Illumina (NovaSeq, NextSeq, MiSeq) as well as Oxford Nanopore (GridION).

Together with the bioinformatics facility, we ensure high-quality data production and continuously update our workflows. Advising on experimental settings and training is a very important aspect of our work. Especially young researchers profit at the beginning of their career from hands-on courses using specialized, sophisticated equipment.

Selected Publications

Arrigoni L, Ferrari F, Weller J, Bella C, Bönisch U, Manke T (2020)
AutoRELACS: automated generation and analysis of ultra-parallel ChIP-seq
Scientific Reports 10(1), 12400.
Arrigoni L, Al-Hasani H, Ramírez F, Panzeri I, Ryan DP, Santacruz D, Kress N, Pospisilik JA, Bönisch U, Manke T (2018)
RELACS nuclei barcoding enables high-throughput ChIP-seq
Communications Biology 1, 214.
Anatskiy E, Ryan DP, Grüning BA, Arrigoni L, Manke T, Bönisch U (2019)
Parkour LIMS: high-quality sample preparation in next generation sequencing
Bioinformatics 35(8), 1422-1424.
Stunnenberg, HG, The International Human Epigenome Consortium (2016)
The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery
Cell 167(5), 1145-1149.
Arrigoni L, Richter AS, Betancourt E, Bruder K, Diehl S, Manke T and Bönisch U (2016)
Standardizing chromatin research: a simple and universal method for ChIP-seq.
Nucleic Acids Research 44(7), e67.
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