Research

Group Leader

Prof. Dr. Thomas Jenuwein

Senior Group Leader & Director

Phone:+49 761 5108 785

Email:jenuwein@...

Lab Thomas Jenuwein

Assistant: Marcela Mare Phone: +49 761 5108 574 Email: mare@ie-freiburg.mpg.de

Selected Publications

Bulut-Karslioglu A, De La Rosa-Velázquez IA, Ramirez F, Barenboim M, Onishi-Seebacher M, Arand J, Galán C, Winter GE, Engist B, Gerle B, O'Sullivan RJ, Martens JH, Walter J, Manke T, Lachner M, Jenuwein T. (2014)

Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells.

Mol Cell. 55, 277-290

Source

Bulut-Karslioglu A, Perrera V, Scaranaro M, de la Rosa-Velazquez IA, van de Nobelen S, Shukeir N, Popow J, Gerle B, Opravil S, Pagani M, Meidhof S, Brabletz T, Manke T, Lachner M, Jenuwein T. (2012)

A transcription factor-based mechanism for mouse heterochromatin formation.

Nat Struct Mol Biol. 19, 1023-1030

Source

Pinheiro I, Margueron R, Shukeir N, Eisold M, Fritzsch C, Richter FM, Mittler G, Genoud C, Goyama S, Kurokawa M, Son J, Reinberg D, Lachner M, Jenuwein T. (2012)

Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity.

Cell 150, 948-960

Source

Fodor BD, Shukeir N, Reuter G, Jenuwein T. (2010)

Mammalian Su(var) genes in chromatin control.

Annu Rev Cell Dev Biol. 26, 471-501

Source

Feng W, Yonezawa M, Ye J, Jenuwein T, Grummt I. (2010).

PHF8 activates transcription of rRNA genes by binding to trimethylated H3K4 and demethylating H3K9me1/2

Nat Struct Mol Biol. 17, 445-450

Source

Laboratory Thomas Jenuwein

Epigenetic mechanisms control eukaryotic development beyond DNA-stored information. There are many pathways, such as DNA methylation, nucleosome remodelling, histone modifications, exchange of histone variants and non-coding RNAs that together contribute to differences of the chromatin template. In particular, the great diversity of covalent histone tail modifications has been proposed to reflect an index ('histone code') that can stabilize distinct proliferative and developmental options. We discovered the first histone lysine methyltransferase and then showed that histone lysine methylation represents a central epigenetic modification in eukaryotic chromatin. We are continuing with our analyses on histone lysine methylation to further dissect epigenetic gene regulation and to identify molecular pathways that initiate and maintain heterochromatic domains in mammalian chromatin.