Laboratory Nicola Iovino
Chromatin regulation in early embryo
Fertilisation and early embryogenesis are the foundations of life. Despite much progress in developmental biology, it remains unclear i) how terminally differentiated gametes are reprogrammed to totipotency ii) what is the content and extent of epigenetic information carried from the gametes to the next generation iii) how the de-novo epigenome is established in the early embryo.
The goal of the lab is to break new ground by unravelling the mechanisms that regulate (i) epigenetic reprogramming of gametes, (ii) germline epigenetic inheritance, and (iii) de novo establishment of epigenetic memory. We use Drosophila early embryo as a model system.
These mechanisms are evolutionarily conserved, thus our discoveries will open the way for translational research and novel studies of early embryogenesis that could be applied to vertebrate models.