Laboratory Thomas Boehm

Laboratory Thomas Boehm

Developmental Immunology

Our work aims at understanding the general principles of adaptive immunity. In our analysis we consider as much as is possible the immune systems of species situated at key positions on the vertebrate phylogenetic tree. in the hope of reconstructing the evolutionary transitions that over the course of 500 million years have led to the complex array of immune facilities that we have come to recognize in mammals. In particular, we are interested in studying the evolution of thymopoietic microenvironments, which provide the instructive cues for initiating T cell lineage commitment, supply trophic factors to differentiating and mature cell types, and orchestrate the formation of cell populations expressing diverse and self-tolerant antigen receptor repertoires.

Mission

Our research focuses on the evolution of adaptive immune systems and their design principles. In particular, we study the development and function of the thymus and T cells. We take a comparative approach examining a number of species, ranging from basal vertebrates to humans, with special emphasis on vertebrates with life styles at the extreme ends of the phenotypic spectrum.

Goals

We aim at elucidating the design principles of vertebrate immune systems with a view to contributing to a better understanding of immune system disorders in humans.

Approach

We take a genetic approach to study genes, cell types and lymphoid organs that function in the immune system. We combine phylogenetic studies and genome analyses with forward genetic screens and methods of precise genetic interference in model systems.


Selected Publications

1.
Morimoto R, O´Meara CP, Holland SJ, Trancoso I, Souissi A, Schorpp M, Vassaux D, Iwanami N, Giorgetti OB, Evanno G, Boehm T (2020)
Cytidine deaminase 2 is required for VLRB antibody gene assembly in lampreys
Science Immunology 5, eaba0925.
2.
Swann JB, Holland SJ, Petersen M, Pietsch TW, Boehm T (2020)
Immunogenetics of sexual parasitism
Science 369(6511), 1608-1615.
3.
Iwanami N, Lawir DF, Sikora K, O’Meara C, Takeshita K, Schorpp M, Boehm T (2020)
Transgenerational inheritance of impaired larval T cell development in zebrafish
Nature Communication 11, 4505 (2020)
4.
Swann JB, Nusser A, Morimoto R, Nagakubo D, Boehm T (2020)
Retracing the evolutionary emergence of thymopoiesis
Science Advances 6(48), eabd9585.
5.
Giorgetti OB, Shingate P, O'Meara CP, Ravi V, Pillai NE, Tay BH, Prasad A, Iwanami N, Tan HH, Schorpp M, Venkatesh B, Boehm T (2020)
Antigen receptor repertoires of one of the smallest known vertebrates
Science Advances 7(1), eabd8180.

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