Fly Facility

Fly Facility

Plamen Georgiev in conversation with a fly facility user.

The fruit fly Drosophila is one of the most extensively characterized metazoan organisms. Over more than 100 years since it was introduced as an experimental animal model for biological research, it has allowed for key biological concepts and phenomena to be elucidated, leading to some of biology’s fundamental findings, including the chromosomal theory of heredity and basic genetic mechanisms underlying animal development and evolution.

Importantly, many aspects of development and behaviour in Drosophila parallel those in humans. The completion of both the human and Drosophila genome sequencing projects revealed that more than 75% of human genetic disease genes have clear homologues in the fruit fly. Taking advantage of the significantly shorter life cycle and powerful array of genetic and molecular tools available in Drosophila, it is now feasible to perform large-scale genetic screens in Drosophila to identify novel drugs and therapeutic targets.


Selected Publications

1.
Keller Valsecchi CI, Marois E, Basilicata MF, Georgiev P, Akhtar A (2021)
Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and Drosophila.
Life Science Alliance 4(9):e202000996.
2.
Keller Valsecchi CI , Basilicata MF, Georgiev P, Gaub A, Seyfferth J, Kulkarni T, Panhale A, Semplicio G, Manjunath V, Holz H, Dasmeh P, Akhtar A (2021)
RNA nucleation by MSL2 induces selective X chromosome compartmentalization
Nature 589(7840), 137-142.
3.
Samata M, Alexiadis A, Richard G, Georgiev P, Nübler J, Kulkarni T, Renschler G,  Basilicata MF, Zenk FL, Shvedunova M, Semplicio G, Mirny L, Iovino N and Akhtar A (2020)
Intergenerationally maintained Histone H4 lysine 16 acetylation is instructive for future gene activation
Cell 182(1), 127-144.e23.
4.
Lam KC, Chung HR, Semplicio G, Iyer SS, Gaub A, Bhardwaj V, Holz H, Georgiev P, Akhtar A (2019)
The NSL complex-mediated nucleosome landscape is required to maintain transcription fidelity and suppression of transcription noise.
Genes Development 33(7-8), 452-465.
5.
Valsecchi CIK, Basilicata MF, Semplicio G, Georgiev P, Gutierrez NM, Akhtar A (2018)
Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells.
Nature Communications 9(1):3626.
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