The role of molecular chaperones during transcription: implications in biomedicine and evolution

Molecular chaperones are known for their role in folding of proteins in the cytosol. The research focus of the research group is to study these chaperones operating at chromatin, at sites of gene expression. In 2015, two important aspects of chaperoning at chromatin were discovered. Firstly, the mechanistic basis of buffering of genetic variation in gene promoters was elucidated. Secondly, an unbiased interaction network of Hsp90 at chromatin was uncovered in human cells paving a way for understanding anti-cancer properties of Hsp90 inhibitors.