Developmental Epigenetics
Department
The Department of Developmental Epigenetics is headed by Nicola Iovino and dedicated to exploring how epigenetic mechanisms shape biological diversity and drive evolutionary processes. We employ a broad array of techniques, from classical molecular biology and genetic approaches to cutting-edge genomics and imaging technologies. Our stimulating scientific environment attracts curious students and postdocs actively engaged in diverse research projects.
Epigenetics involves changes in chromatin (the complex of DNA and proteins) that alter gene expression without affecting the underlying DNA sequence. For changes to be considered truly epigenetic, they must persist through cell division or generations. Our research aims to uncover how epigenetic mechanisms enable a fertilized oocyte (zygote) to develop into a multicellular organism with diverse shapes and functions. Such questions have intrigued humankind since Aristotle's time and remain some of the most fascinating and unsolved mysteries.
Our research spans generations to elucidate the role of inherited epigenetic information. Growing evidence suggests that epigenetic information is transmitted from parents to offspring, playing an instructive role in early embryonic development. These discoveries challenge long-standing dogmas that the zygote erases all epigenetic marks carried by the gametes. Our pioneering work has highlighted the importance of inherited histone modifications in embryonic development. For instance, our studies with fruit flies (Drosophila melanogaster) have shown that certain modifications, like H3K27me3 and H3K9me3, can persist across generations, regulating gene activity during early development.
We aim to further understand how both inherited and newly formed chromatin matures during early development. Our research focuses on chromatin remodeling and histone modification, the 3D organization of the genome, and embryonic genome activation in organisms as phylogenetically distant as fruit flies and mammals.
Ultimately, our long-term goal is to uncover how epigenetic changes influence gene expression and help organisms adapt to their environment, potentially revealing new principles underlying biological diversity and evolution.
