Max Planck Institute of Immunobiology and Epigenetics

Awakening Stem Cells with Vitamins

Video May 11, 2017

© DKFZ Heidelberg

Video abstract for Cell 169(5), 2017

Billions of blood cells die every day and need to be replaced by new ones. In this video, Andreas Trumpp (DKFZ) and group leader Nina Cabezas-Wallscheid show that Vitamin A is a key signal that controls both the transition of hematopoietic stem cells from a "sleep-mode" state called dormancy to an active state and how Vitamin A metabolites may help to improve treatment of blood disorders and leukemias.

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Cabezas-Wallscheid, N.; Buettner, F.; Sommerkamp, P.; Klimmeck, D.; Ladel, L.; Thalheimer, F. B.; Pastor-Flores, D.; Roma, L. P.; Renders, S.; Zeisberger, P. et al.; Przybylla, A.; Schönberger, K.; Scognamiglio, R.; Altamura, S.; Florian, C. M.; Fawaz, M.; Vonficht, D.; Tesio, M.; Collier, P.; Pavlinic, D.; Geiger, H.; Schroeder, T.; Benes, V.; Dick, T. P.; Rieger, M. A.; Stegle, O.; Trumpp, A.: Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy. Cell 169, pp. 807 - 823 (2017)

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