The important contribution of quantitative proteomics for deciphering the gene-regulatory code fo the human genome

Research report (imported) 2008 - Max Planck Institute of Immunobiology and Epigenetics

Authors
Mittler, Gerhard
Departments
Zelluläre und molekulare Immunologie (Prof. Dr. Rudolf Grosschedl)
MPI für Immunbiologie, Freiburg
Summary
The human genome contains roughly 25,000 protein-coding genes. However, in a given cell-type a maximum of only 10,000 of these genes are expressed at a significant level. In order to understand this, scientists have to know the gene regulatory code, which consists of the DNA sequence-dependent binding specificities of a prominent class of DNA-binding proteins, the so called transcription factors (TFs), which are able to read the regulatory information. Max-Planck researchers have devised a fast and sensitive technology bearing the potential for genome-wide studies of the gene regulatory code.

For the full text, see the German version.

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