Laboratory Michael Reth
Research in the Department of Molecular Immunology seeks a better understanding of the organisation and regulation of receptors and intracellular signalling pathways in normal and diseased lymphocytes. Our research is largely focused on the development and function of B lymphocytes. We have proposed a new model for the structure and activation of the B cell antigen receptor (BCR) and have discovered new signalling components in activated B cells. We also developed techniques for a more profound study of signalling mechanism in resting and activated B cells. Several of our findings have contributed to a better understanding of human diseases such as leukemias and autoimmunity. Furthermore, we are among the first to adapt synthetic biology approaches for studying signalling in mammalian cells. In a collaboration between the University of Freiburg and the MPI, the department also organizes an advanced study program for molecular immunology. This popular program started in 1997 and attracts students both from Freiburg and from other Universities.