Group Leader

Prof. Dr.  Michael Reth
Prof. Dr. Michael Reth
Adjunct Scientific Member of the MPG (MPI-IE/Uni)
Phone:+49 761 203-2718

Institute of Biology III (Molecular Immunology), University of Freiburg

Michael Reth @ BIOSS Freiburg

Miriam Vitt
Assistant to Michael Reth
Phone:+49 761 203-2868

Short CV

1950 Born in Düsseldorf, Germany; Undergraduate Studies in Biology, University of Cologne

1977-1981 PhD studies at University of Cologne

1982-1985 Postdoctoral studies Columbia University, New York

1985-1988 Assistant Professor University of Cologne

1989-1996 Associate Professor Max Planck Institute of Immunobiology, Freiburg

Since 1996 Professor at the University of Freiburg, Head of the Department of Molecular Immunobiology

Since 2007 Scientific director of the Center for Biological Signalling Studies (BIOSS) funded by the excellence program of the German government

Selected Publications

Kläsener K, Maity PC, Hobeika E, Yang J, Reth M.
B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk.
Reth, M. (2013)
Matching cellular dimensions with molecular sizes.
Thedieck, K., B. Holzwarth, et al. (2013)
Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells.
Yang, J. and M. Reth (2010)
Oligomeric organization of the B-cell antigen receptor on resting cells.
Yang, J. and M. Reth (2010).
The dissociation activation model of B cell antigen receptor triggering

Laboratory Michael Reth

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Laboratory Michael Reth

Research in the Department of Molecular Immunology seeks a better understanding of the organisation and regulation of receptors and intracellular signalling pathways in normal and diseased lymphocytes. Our research is largely focused on the development and function of B lymphocytes. We have proposed a new model for the structure and activation of the B cell antigen receptor (BCR) and have discovered new signalling components in activated B cells. We also developed techniques for a more profound study of signalling mechanism in resting and activated B cells. Several of our findings have contributed to a better understanding of human diseases such as leukemias and autoimmunity. Furthermore, we are among the first to adapt synthetic biology approaches for studying signalling in mammalian cells. In a collaboration between the University of Freiburg and the MPI, the department also organizes an advanced study program for molecular immunology. This popular program started in 1997 and attracts students both from Freiburg and from other Universities.

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