Carlos Alfonso Gonzalez

from Queretaro, Mexico
IMPRS doctoral researcher since September 2018 in Hilgers lab
Research interestsCircular RNAs are single stranded RNA molecules covalently closed into a continuous loop structure that result from back-splicing of precursor messenger RNAs. Currently, the functional regulation of circRNAs is not well understood. In tissue culture two core complexes have been implicated into circRNA formation: (1) the spliceosome and (2) the cleavage and polyadenlyation machinery. ELAV is a major regulator of both alternative splicing (AS) and alternative polyadenylation (APA) in the Drosophila nervous system. My project aims to uncover the role that ELAV holds in neuron-specific circRNA regulation mediating the homeostasis between linear and circular transcripts.

Research interests
Circular RNAs are single stranded RNA molecules covalently closed into a continuous loop structure that result from back-splicing of precursor messenger RNAs. Currently, the functional regulation of circRNAs is not well understood. In tissue culture two core complexes have been implicated into circRNA formation: (1) the spliceosome and (2) the cleavage and polyadenlyation machinery. ELAV is a major regulator of both alternative splicing (AS) and alternative polyadenylation (APA) in the Drosophila nervous system. My project aims to uncover the role that ELAV holds in neuron-specific circRNA regulation mediating the homeostasis between linear and circular transcripts.
 
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