Group Leader

Dr. Nina Cabezas-Wallscheid
Dr. Nina Cabezas-Wallscheid
Group Leader
Phone:+49 761 5108-530

Lab Nina Cabezas-Wallscheid

Laboratory Nina Cabezas-Wallscheid

Header image 1520876339

Publications (2007-2017)

Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis
Giladi A, Paul F, Herzog Y, Lubling Y, Weiner A, Yofe I, Jaitin D, Cabezas-Wallscheid N, Dress R, Ginhoux F, Trumpp A, Tanay A, Amit I. (2018)
Nature Cell Biology 20, 836-846.

Vitamin C: C-ing a New Way to Fight Leukemia
Schönberger K, Cabezas-Wallscheid N (2017)
Cell Stem Cell 21(5), 561-563.

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy
Cabezas-Wallscheid N, Buettner F, Sommerkamp P, Klimmeck P, Ladel L, Thalheimer FB, Pastor-Flores D, Roma LP, Renders S, Zeisberger P,  Przybylla A, Schönberger K, Scognamiglio R, Altamura S, Florian KM, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinic D, Geiger H, Schroeder T, Benes V, Dick TP, Rieger MA, Stegle O, Trumpp A (2017)
Cell 169(5):1-17; published online: May 4, 2017.

“Potency finds its niches”. Stem Cells.
Cabezas-Wallscheid N, Trumpp A. (2016)
Science. 351(6269):126-7.

Myc depletion induces a pluripotent dormant State mimicking diapause
Scognamiglio R, Cabezas-Wallscheid N, Thier MC, Altamura S, Reyes A, Prendergast ÁM, Baumgärtner D, Carnevalli LS, Atzberger A, Haas S, von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, Trumpp A. (2016)
Cell. 164(4):668-80.

  • Cover of the Cell February Issue
  • Previewed by Xiaodong Shu and Duanqing Pei in Cell. “Pluripotency without proliferation“
  • Previewed by Nakagawa M, Karagiannis P, Yamanaka S in EMBO Journal. “When Myc's asleep, embryonic stem cells are dormant“

Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis
Cabezas-Wallscheid N*, Klimmeck D*, Hansson J*, Lipka DB*, Reyes A*, Wang Q, Weichenhan D, Lier A, von Paleske L, Renders S, Wünsche P, Zeisberger P, Brocks D, Gu L, Herrmann C, Haas S, Essers MA, Brors B, Eils R, Huber W, Milsom MD, Plass C, Krijgsveld J, Trumpp A. (2014) (*co-first authors)
Cell Stem Cell. 15(4):507-22.

  • Cover of the Cell Stem Cell October Issue
  • Top 5% of all Cell Stem Cell articles ranked by attention on Aug. 2015 (Article Level Metrics; Cell Press)
  • Previewed by D. Kalaitzidis and D.T. Scadden in EMBO Journal. “Deep diving in the blood stem cell-ome”

Transcriptional landscape, long non-coding RNAs and post transcriptional regulation in hematopoietic stem/progenitor cell commitment
Klimmeck D*, Cabezas-Wallscheid N*, Reyes A*, von Paleske L, Renders S, Hansson J, Krijgsveld J, Huber W, Trumpp A. (2014) (*co-first authors)
Stem Cell Reports. 11;3(5):858-75.

Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing
Lipka DB*, Wang Q*, Cabezas-Wallscheid N*, Klimmeck D*, Weichenhan D, Herrmann C, Lier A, Brocks D, von Paleske L, Renders S, Wünsche P, Zeisberger P, Gu L, Haas S, Essers MA, Brors B, Eils R, Trumpp A, Milsom MD, Plass C. (2014) (*co-first authors)
Cell Cycle. 13(22):3476-3487.

  • Previewed by SM. Cullen and MA. Goodell in Cell Cycle. “Dynamic DNA methylation discovered during HSC differentiation”

Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking Granzyme B
Carnevalli LS, Scognamiglio R, Cabezas-Wallscheid N, Rahmig S, Laurenti E, Masuda K, Jöckel L, Kuck A, Sujer S, Polykratis A, Erlacher M, Pasparakis M, Essers MA, Trumpp A. (2014)
J Exp Med. 211(5):769-79.

Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model
Cabezas-Wallscheid N, Eichwald V, de Graaf J, Löwer M, Lehr HA, Kreft A, Eshkind L, Hildebrandt A, Abassi Y, Heck R, Dehof AK, Ohngemach S, Sprengel R, Wörtge S, Schmitt S, Lotz J, Meyer C, Kindler T, Zhang DE, Kaina B, Castle JC, Trumpp A, Sahin U, Bockamp E. (2013)
EMBO Mol Med. 5(12):1804-20.

  • Previewed by J. Mulloy in EMBO Mol Med. “A new inducible model for t(8;21) AML”

Tetracycline-controlled transgene activation using the ROSA26-iM2-GFP knock-in mouse strain permits GFP monitoring of DOX-regulated transgene-expression
Wörtge S, Eshkind L, Cabezas-Wallscheid N, Lakaye B, Kim J, Heck R, Abassi Y, Diken M, Sprengel R, Bockamp E. (2010)
BMC Dev Biol 10:95.

In vivo fate mapping with SCL regulatory elements identifies progenitors for primitive and definitive hematopoiesis in mice
Bockamp E, Antunes C, Liebner S, Schmitt S, Cabezas-Wallscheid N, Heck R, Ohnngemach S, Oesch-Bartlomowicz B, Rickert C, Sanchez MJ, Hengstler J, Kaina B, Wilson A, Trumpp A, Eshkind L. (2009)
Mech Dev. 126(10):863-72.

Generation and characterization of tTS-H4: a novel transcriptional repressor that is compatible with the reverse tetracycline-controlled TET-ON system
Bockamp E, Christel C, Hameyer D, Khobta A, Maringer M, Reis M, Heck R, Cabezas-Wallscheid N, Epe B, Oesch-Bartlomowicz B, Kaina B, Schmitt S, Eshkind L. (2007)
J Gene Med 9(4):308-18.

 
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