Epithelial tissues form a barrier between the external environments and internal organs. This exposed position of epithelia makes them susceptible to injury and damage. The restoration of tissue integrity after damage depends on the interactions between stress signalling pathways and cell populations around the damaged tissue. While it is well-established in the tissue repair context that chromatin dynamics change dramatically due to these interactions, the main program driving the alterations is not well-characterized. My PhD project aims to characterize the fundamental chromatin reorganization program in wound healing and tissue regeneration processes by using Drosophila wing imaginal disc model.