Research interests
My research investigates the crucial interaction between gut microbiota metabolites and human cellular function. I focus on how microbial-derived small molecules influence chromatin regulation and epigenetic mechanisms across various cell types. Using innovative high-throughput screening systems combined with culturomics, I identify specific bacterial metabolites that modulate chromatin function in both differentiated and pluripotent cells. My approach integrates multi-omics analysis (metabolomics, transcriptomics, and epigenomics) with advanced cell culture techniques to characterize these regulatory interactions. This work extends from in vitro cell systems to in vivo validation using gnotobiotic mouse models, aiming to elucidate how the gut microbiome's metabolic output influences distant tissue function and embryonic development through epigenetic pathways.
