Epigenetic identity and nuclear organization of centromeres

Research report (imported) 2013 - Max Planck Institute of Immunobiology and Epigenetics

Authors
Padeken, Jan; Mendiburo, María José; Olszak, Agata; Schwarz, Hans-Jürgen; Heun, Patrick
Departments
Abteilung Molekulare und Zelluläre Immunologie
Summary
Centromeres are specialized genomic regions essential for proper chromosome segregation to the daughter cells. The researchers are interested in understanding how their identity and nuclear organization is regulated. Using the fruit fly Drosophila melanogaster it was recently shown that the centromere-specific histone CENP-A is a key epigenetic mark for centromere identity, both necessary and sufficient for centromere formation. We further identified Nucleoplasmin (NLP) to play a major role in the positioning of centromeres in the nucleus.

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