Signalling fire of haematopoiesis

Hematopoietic stem cells (HSCs) are a rare population capable of giving rise to all blood cells in our body. Understanding the molecular mechanisms of their development and maintenance can bring insights into how we could manipulate them ex vivo and treat hematological diseases. We use zebrafish and mouse as models to study HSC biology and focus on the role of inflammatory signaling in HSC generation during development but also HSC maintenance in adulthood. We are interested in transcription factors that cause HSC generation and are often deregulated in hematological diseases, like leukemia.