Max Planck Institute of Immunobiology and Epigenetics

Publications

Lab Lämmermann

2023

Kaltenbach, L.; Martzloff, P.; Bambach, S. K.; Aizarani, N.; Mihlan, M.; Gavrilov, A.; Glaser, K. M.; Stecher, M.; Thünauer, R.; Thiriot, A. et al.; Heger, K.; Kierdorf, K.; Wienert, S.; von Andrian, U. H.; Schmidt-Supprian, M.; Nerlov, C.; Klauschen, F.; Roers, A.; Bajénoff, M.; Grün, D.; Lämmermann, T.: Slow integrin-dependent migration organizes networks of tissue-resident mast cells. Nature Immunology (2023)

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Zink, A.; Zenke, S.; Wiese, T.; Beyersdorf, N.; Lämmermann, T.; Rohr, J. C.: Analyzing trogocytosis of T lymphocytes by flow cytometry and confocal microscopy. STAR Protocols 4, 102013 (2023)

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Schönberger, K.; Mitterer, M.; Glaser, K.; Stecher, M.; Hobitz, S.; Schain-Zota, D.; Schuldes, K.; Lämmermann, T.; Rambold, A.; Cabezas-Wallscheid, N. et al.; Büscher, J. M.: LC-MS-Based Targeted Metabolomics for FACS-Purified Rare Cells. Analytical Chemistry 95, pp. 4325 - 4334 (2023)

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2022

Glaser, K. M.; Tarrant, T. K.; Lämmermann, T.: Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions. Frontiers in immunology 13, 1039803 (2022)

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Zenke, S.; Sica, M. P.; Steinberg, F.; Braun, J.; Zink, A.; Gavrilov, A.; Hilger, A.; Arra, A.; Brunner-Weinzierl, M.; Elling, R. et al.; Beyersdorf, N.; Lämmermann, T.; Smulski, C. R.; Rohr, J. C.: Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation. Nature Communications 13, 6459 (2022)

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Mihlan, M.; Safaiyan, S.; Stecher, M.; Paterson, N.; Lämmermann, T.: Surprises from Intravital Imaging of the Innate Immune Response. Annual Review of Cell and Developmental Biology 38, pp. 18.1 - 18.23 (2022)

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Georgantzoglou, A.; Poplimont, H.; Walker, H. A.; Lämmermann, T.; Sarris, M.: A two-step search and run response to gradients shapes leukocyte navigation in vivo. Journal of Cell Biology 221, e202103207 (2022)

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Masuda, T.; Amann, L.; Monaco, G.; Sankowski, R.; Staszewski, O.; Krueger, M.; Gaudio, F. D.; He, L.; Paterson, N.; Nent, E. et al.; Fernández-Klett, F.; Yamasaki, A.; Frosch, M.; Fliegauf, M.; Bosch, L. F. P.; Ulupinar, H.; Hagemeyer, N.; Schreiner, D.; Dorrier, C.; Tsuda, M.; Grothe, C.; Joutel, A.; Daneman, R.; Betsholtz, C.; Lendahl, U.; Knobeloch, K.-P.; Lämmermann, T.; Priller, J.; Kierdorf, K.; Prinz, M.: Specification of CNS macrophage subsets occurs postnatally in defined niches. Nature 604, pp. 740 - 748 (2022)

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Mihlan, M.; Glaser, K. M.; Epple, M. W.; Lämmermann, T.: Neutrophils: Amoeboid Migration and Swarming Dynamics in Tissues. Frontiers in Cell and Developmental Biology 10, 871789 (2022)

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Jünger, F.; Ruh, D.; Strobel, D.; Michiels, R.; Huber, D.; Brandel, A.; Madl, J.; Gavrilov, A.; Mihlan, M.; Daller, C. C. et al.; Rog-Zielinska, E. A.; Römer, W.; Lämmermann, T.; Rohrbach, A.: 100 Hz ROCS microscopy correlated with fluorescence reveals cellular dynamics on different spatiotemporal scales. Nature Communications 13, 1758 (2022)

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Paterson, N.; Lämmermann, T.: Macrophage network dynamics depend on haptokinesis for optimal local surveillance. eLife 11, e75354, pp. 1 - 32 (2022)

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Mossad, O.; Batut, B.; Yilmaz, B.; Dokalis, N.; Mezö, C.; Nent, E.; Nabavi, L. S.; Mayer, M.; Maron, F. J. M.; Büscher, J. M. et al.; de Agüero, M. G.; Szalay, A.; Lämmermann, T.; Macpherson, A. J.; Ganal-Vonarburg, S. C.; Backofen, R.; Erny, D.; Prinz, M.; Blank, T.: Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N⁶-carboxymethyllysine. Nature Neuroscience 25, pp. 295 - 305 (2022)

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Groß, M.; Speckmann, C.; May, A.; Gajardo-Carrasco, T.; Wustrau, K.; Maier, S. L.; Panning, M.; Huzly, D.; Agaimy, A.; Bryceson, Y. T. et al.; Choo, S.; Chow, C. W.; Dückers, G.; Fasth, A.; Fraitag, S.; Gräwe, K.; Haxelmans, S.; Holzinger, D.; Hudowenz, O.; Hübschen, J.; Khurana, C.; Kienle, K.; Klifa, R.; Korn, K.; Kutzner, H.; Lämmermann, T.; Ledig, S.; Lipsker, D.; Meeths, M.; Naumann-Bartsch, N.; Rascon, J.; Schänzer, A.; Seidl, M.; Tesi, B.; Vauloup-Fellous, C.; Vollmer-Kary, B.; Warnatz, K.; Wehr, C.; Neven, B.; Vargas, P.; Sepulveda, F. E.; Lehmberg, K.; Schmitt-Gräff, A.; Ehl, S.: Rubella vaccine-induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity. The journal of allergy and clinical immunology: official publication of the American Academy of Allergy, Asthma and Immunology 149, pp. 388 - 399 (2022)

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2021

Mossad, O.; Nent, E.; Woltemate, S.; Folschweiller, S.; Büscher, J. M.; Schnepf, D.; Erny, D.; Staeheli, P.; Bartos, M.; Szalay, A. et al.; Stecher, B.; Vital, M.; Sauer, J. F.; Lämmermann, T.; Prinz, M.; Blank, T.: Microbiota-dependent increase in δ-valerobetaine alters neuronal function and is responsible for age-related cognitive decline. Nature aging 1, pp. 1127 - 1136 (2021)

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Glaser, K. M.; Mihlan, M.; Lämmermann, T.: Positive feedback amplification in swarming immune cell populations. Current Opinion in Cell Biology 72, pp. 156 - 162 (2021)

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Barkaway, A.; Rolas, L.; Joulia, R.; Bodkin, J.; Lenn, T.; Owen-Woods, C.; Reglero-Real, N.; Stein, M.; Vázquez-Martínez, L.; Girbl, T. et al.; Poston, R. N.; Golding, M.; Saleeb, R. S.; Thiriot, A.; von Andrian, U. H.; Duchene, J.; Voisin, M.-B.; Bishop, C. L.; Voehringer, D.; Roers, A.; Rot, A.; Lämmermann, T.; Nourshargh, S.: Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage. Immunity 54, pp. 1494 - 1510 (2021)

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Kienle, K.; Glaser, K. M.; Eickhoff, S.; Mihlan, M.; Knöpper, K.; Reátegui, E.; Epple, M. W.; Gunzer, M.; Baumeister, R.; Tarrant, T. K. et al.; Germain, R. N.; Irimia, D.; Kastenmüller, W.; Lämmermann, T.: Neutrophils self-limit swarming to contain bacterial growth in vivo. Science 372, eabe7729 (2021)

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Arasa, J.; Collado-Diaz, V.; Kritikos, I.; Medina-Sanchez, J. D.; Friess, M. C.; Sigmund, E. C.; Schineis, P.; Hunter, M. C.; Tacconi, C.; Paterson, N. et al.; Nagasawa, T.; Kiefer, F.; Makinen, T.; Detmar, M.; Moser, M.; Lämmermann, T.; Halin, C.: Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation. Journal of Experimental Medicine 218, p. e20201413 (2021)

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2020

Sixt, M.; Lämmermann, T.: T cells: Bridge-and-Channel Commute to the White Pulp. Immunity 52, pp. 721 - 723 (2020)

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Zenke, S.; Palm, M. M.; Braun, J.; Gavrilov, A.; Meiser, P.; Böttcher, J. P.; Beyersdorf, N.; Ehl, S.; Gerard, A.; Lämmermann, T. et al.; Schumacher, T. N.; Beltman, J. B.; Rohr, J. C.: Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics. Immunity 52, pp. 313 - 327 (2020)

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2019

Uderhardt, S.; Martins, A. J.; Tsang, J. S.; Lämmermann, T.; Germain, R. N.: Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell 177, pp. 541 - 555 (2019)

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Mauler, M.; Herr, N.; Schoenichen, C.; Witsch, T.; Marchini, T.; Härdtner, C.; Koentges, C.; Kienle, K.; Ollivier, V.; Schell, M. et al.; Dorner, L.; Wippel, C.; Stallmann, D.; Normann, C.; Bugger, H.; Walther, P.; Wolf, D.; Ahrens, I.; Lämmermann, T.; Ho-Tin-Noé, B.; Ley, K.; Bode, C.; Hilgendorf, I.; Duerschmied, D.: Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation. Circulation 139, pp. 918 - 931 (2019)

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Kolter, J.; Feuerstein, R.; Zeis, P.; Hagemeyer, N.; Paterson, N.; d’Errico, P.; Baasch, S.; Amann, L.; Masuda, T.; Lösslein, A. et al.; Gharun, K.; Meyer-Luehmann, M.; Waskow, C.; Franzke, C.-W.; Grün, D.; Lämmermann, T.; Prinz, M.; Henneke, P.: A Subset of Skin Macrophages Contributes to the Seruveillance and Regeneration of Local Nerves. Immunity 50, pp. 1482 - 1497 (2019)

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Lämmermann, T.; Kastenmüller, W.: Concepts of GPCR-controlled navigation in the immune system. Immunological Reviews 289, pp. 205 - 231 (2019)

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2018

Hülsdünker, J.; Ottmüller, K. J.; Neeff, H. P.; Koyama, M.; Gao, Z.; Thomas, O. S.; Follo, M.; Al-Ahmad, A.; Prinz, G.; Duquesne, S. et al.; Dierbach, H.; Kirschnek, S.; Lämmermann, T.; Blaser, M. J.; Fife, B. T.; Blazar, B. R.; Beilhack, A.; Hill, G. R.; Häcker, G.; Zeiser, R.: Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset. Blood 131, pp. 1858 - 1869 (2018)

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Andreani, V.; Ramamoorthy, S.; Pandey, A.; Lupar, E.; Nutt, S. L.; Lämmermann, T.; Grosschedl, R.: Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function. Proceedings of the National Academy of Sciences of the United States of America 115, pp. E9630 - E9639 (2018)

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2017

Bambach , S. K.; Lämmermann, T.: Platelets, On Your Makrs, Gest Set, Migrate! Cell 171, pp. 1256 - 1258 (2017)

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Lämmermann, T.: Cell migration: Arraying neutrophils in swarms. nature biomedical engineering 1, p. 0100 (2017)

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2016

Kong, L.; Tang, J.; Little, J. P.; Yu, Y.; Lämmermann, T.; Lin, C. P.; Germain, R. N.; Cui, M.: Continuous volumetric imaging via an optical phase-locked ultrasound lens. Nature methods 12, pp. 759 - 762 (2016)

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Kienle, K.; Lämmermann, T.: Neutrophil swarming: an essential process of the neutrophil tissue response. Immunological Reviews 273, pp. 76 - 93 (2016)

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2014

Honda, T.; Egen, J. G.; Lämmermann, T.; Kastenmüller, W.; Torabi-Parizi, P.; Germain, R. N.: Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function inflammed tissues. Immunity 40, pp. 235 - 247 (2014)

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Lämmermann, T.; Germain, R. N.: The multiple faces of leukocyte interstitial migration. Springer Seminars in Immunopathology 36, pp. 227 - 251 (2014)

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2013

Song, J.; Lokmic, Z.; Lämmermann, T.; Rolf, J.; Wu, C.; Zhang, X.; Hallmann, R.; Hannocks, M.-J.; Horn, N.; Ruegg, M. A. et al.; Sonnenberg, A.; Georges-Labouesse, E.; Winkler, T. H.; Kearney, J. F.; Cardell, S.; Sorokin, a. L.: Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. Proceedings of the National Academy of Sciences of the United States of America 110, pp. E2915 - E2924 (2013)

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Lämmermann, T.; Afonso, P. V.; Angermann, B. R.; Wang, J. M.; Kastenmüller, W.; Parent, C. A.; Germain, R. N.: Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Nature 498, pp. 371 - 375 (2013)

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2012

Kastenmüller, W.; Torabi-Parizi, P.; Subramanian, N.; Lämmermann, T.; Germain, R. N.: A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread. Cell 150, pp. 1235 - 1248 (2012)

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Gaiser, M. R.; Lämmermann, T.; Feng, X.; Igyarto, B. Z.; Kaplan, D. H.; Tessarollo, L.; Germain, R. N.; Udey, a. M. C.: Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo. Proceedings of the National Academy of Sciences of the United States of America 109, pp. E889 - E897 (2012)

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2011

Sixt, M.; Lämmermann, T.: In vitro analysis of chemotactic leukocyte migration in 3D environments. Methods in Molecular Biology 32, pp. 703 - 713 (2011)

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2010

Schumann, K.; Lämmermann, T.; Bruckner, M.; Legler, D. F.; Polleux, J.; Spatz, J. P.; Schuler, G.; Förster, R.; Lutz, M. B.; Sorokin, L. et al.; Sixt, M.: Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells. Immunity 32 (5), pp. 703 - 713 (2010)

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2009

Renkawitz, J.; Schumann, K.; Weber, M.; Lämmermann, T.; Pflicke, H.; Piel, M.; Polleux, J.; Spatz, J. P.; Sixt, M.: Adaptive force transmission in amoeboid cell migration. Nature Cell Biology 11, pp. 1438 - 1443 (2009)

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Lämmermann, T.; Sixt, M.: Mechanical modes of 'amoeboid' cell migration. Current Opinion in Cell Biology 21, pp. 636 - 644 (2009)

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Lämmermann, T.; Renkawitz, J.; Wu, X.; Hirsch, K.; Brakebusch, C.; Sixt, M.: Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration. Blood 113, pp. 5703 - 5710 (2009)

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Quast, T.; Tappertzhofen, B.; Schild, C.; Grell, J.; Czeloth, N.; Förster, R.; Alon, R.; Fraemohs, L.; Dreck, K.; Weber, C. et al.; Lämmermann, T.; Sixt, M.; Kolanus, W.: Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells. Blood 113, pp. 5801 - 5810 (2009)

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2008

Kessenbrock, K.; Fröhlich, L.; Sixt, M.; Lämmermann, T.; Pfister, H.; Bateman, A.; Belaaouaj, A.; Ring, J.; Ollert, M.; Fässler, R. et al.; Jenne, D. E.: Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. Journal of Clinical Investigation (New York, NY) 118, pp. 2438 - 2447 (2008)

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Lämmermann, T.; Bader, B. L.; Monkley, S. J.; Worbs, T.; Wedlich-Söldner, R.; Hirsch, K.; Keller, M.; Förster, R.; Critchley, D. R.; Fässler, R. et al.; Sixt, M.: Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature 453, pp. 51 - 55 (2008)

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Lämmermann, T.; Sixt, M.: The microanatomy of T-cell responses. Immunological Reviews 221, pp. 26 - 43 (2008)

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Lokmic, Z.; Lämmermann, T.; Sixt, M.; Cardell, S.; Hallmann, R.; Sorokin, L.: The extracellular matrix of the spleen as a potential organizer of immune cell compartments. Seminars in Immunology 20, pp. 4 - 13 (2008)

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2006

Sixt, M.; Bauer, M.; Lämmermann, T.; Fässler, R.: β1 integrins: zip codes and signaling relay for blood cells. Current Opinion in Cell Biology 18, pp. 482 - 490 (2006)

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Chu, H.; Thievessen, I.; Sixt, M.; Lämmermann, T.; Waisman, A.; Braun, A.; Noegel, A. A.; Fässler, R.: γ-Parvin Is Dispensable for Hematopoiesis, Leukocyte Trafficking, and T-Cell-Dependent Antibody Response. Molecular and Cellular Biology (Washington, DC) 26, pp. 1817 - 1825 (2006)

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