Immune tolerance induction in the gut

Research report (imported) 2011 - Max Planck Institute of Immunobiology and Epigenetics

Izcue, Ana
Developmental Immunology (Lab Ana Izcue)
MPI für Immunbiologie und Epigenetik;
Centrum für Chronische Immundefizienz (Gruppenleiter)

Functional immune systems rely on tolerance to self and harmless components of food and microflora. In mammals, immune tolerance is achieved through several mechanisms including a specialised T cell subset with a high constitutive expression of the transcription factor Foxp3. These so called regulatory T cells are especially important in the gut. The team of Ana Izcue analyses the factors required for the activity of regulatory T cells in vivo.

For the full text, see the German version.

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