Immune tolerance induction in the gut
Research report (imported) 2011 - Max Planck Institute of Immunobiology and Epigenetics
Functional immune systems rely on tolerance to self and harmless components of food and microflora. In mammals, immune tolerance is achieved through several mechanisms including a specialised T cell subset with a high constitutive expression of the transcription factor Foxp3. These so called regulatory T cells are especially important in the gut. The team of Ana Izcue analyses the factors required for the activity of regulatory T cells in vivo.