The Stability of Bob1 in B Cells

Research report (imported) 2010 - Max Planck Institute of Immunobiology and Epigenetics

Nielsen, Peter
Molekulare Immunologie (Reth)
Max-Planck-Institut für Immunbiologie und Epigenetik, Freiburg
Bob1 (also called OBF-1 or OCA-B) is a lymphoid transcription factor. While loss of Bob1 leads to impaired B-cell development and activation, over-expression of Bob1 could contribute to B-cell lymphomas. The amount of Bob1 protein in B-cells appears to be largely controlled by protein stability. Scientists at the Max Planck Institute for Immunology and Epigenetics are investigating how Bob1 stability is regulated during B-cell development.

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