The important contribution of quantitative proteomics for deciphering the gene-regulatory code fo the human genome

Research report (imported) 2008 - Max Planck Institute of Immunobiology and Epigenetics

Mittler, Gerhard
Zelluläre und molekulare Immunologie (Prof. Dr. Rudolf Grosschedl)
MPI für Immunbiologie, Freiburg
The human genome contains roughly 25,000 protein-coding genes. However, in a given cell-type a maximum of only 10,000 of these genes are expressed at a significant level. In order to understand this, scientists have to know the gene regulatory code, which consists of the DNA sequence-dependent binding specificities of a prominent class of DNA-binding proteins, the so called transcription factors (TFs), which are able to read the regulatory information. Max-Planck researchers have devised a fast and sensitive technology bearing the potential for genome-wide studies of the gene regulatory code.

For the full text, see the German version.

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