Mediators of Transcriptional Regulation
Research report (imported) 2006 - Max Planck Institute of Immunobiology and Epigenetics
All protein coding genes are transcribed by RNA polymerase II, the central enzyme in gene expression. A Mediator complex forms the bridge between transcriptional regulators and the RNA polymerase II machinery. Scientists at the MPI for Immunobiology recently gained first insights of the physiological function of the Mediator complex by using knock-out mice. They could show that Mediator is an essential coactivator for erythroid master regulator GATA-1. Therefore, mice lacking Mediator subunit Med1/TRAP220 are anemic and have a defect in the red blood cell development.