The adapter protein SLP65 functions as tumour suppressor of childhood leukaemia

Research report (imported) 2003 - Max Planck Institute of Immunobiology and Epigenetics

Authors

Reth, Michael; Jumaa, Hassan

Departments

Forschungsgruppe und Lehrstuhl für Molekulare Immunologie der Universität Freiburg (Prof. Dr. Michael Reth)
MPI für Immunbiologie, Freiburg

Summary

Signal transduction processes regulate the differentiation of B cells. Deregulation may result in immunodeficiency, autoimmunity or lymphoproliferative diseases. Mice lacking the adaptor protein SLP-65 show a block in B cell differentiation and an increased incidence of pre-B cell leukaemia. Moreover, the tumour suppressor function of SLP-65 seems to be required for the inhibition of pre-B cell leukaemia in humans.

For the full text, see the German version.