Zebrafish as a model for immunological research

Research report (imported) 2003 - Max Planck Institute of Immunobiology and Epigenetics

Schorpp, Michael
Entwicklung des Immunsystems (Prof. Dr. Thomas Boehm)
MPI für Immunbiologie, Freiburg
The group of Michael Schorpp at the MPI in Freiburg is interested in identifying genes that are important for thymopoiesis in the zebrafish. They study mutant fish lines that were generated by chemical mutagenesis and display aberrant thymus development. Affected genes are isolated by positional cloning and their biological function elucidated in fish and mice using a variety of methods. These studies are of medical relevance as they might lead to more refined diagnosis and novel therapeutic modalities for inborn or acquired immune deficiency syndromes.

For the full text, see the German version.

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