Ibrahim Cissé - Super-resolution Imaging of Transcription in Live Mammalian Cells

The Cissé lab leverages their expertise in Single Molecule and Super-Resolution imaging in live cells to study collective behaviors (e.g. protein clustering) emerging from weak and transient biomolecular interactions in mammalian cells. This method is used to investigate molecular events that occur when genes are switched on by RNA polymerase II. The activity of this enzyme has been studied primarily in vitro, and surprisingly little is understood about how the polymerase locates and activates its target genes inside the nucleus of living cells. Thus, the lab sets out to understand what roles weak and transient interactions play in regulating genomic processes and nuclear organization at the single-cell level.

The seminar will take place online. If you would like to attend, please contact: Johanna Knipper knipper@ie-freiburg.mpg.de.